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Utilizing a human TLR selective ligand in a humanized immune system mouse model to investigate human TLR4 signaling

Mouse models with humanized immune systems are becoming increasingly prevalent in pharmaceutical research as a platform for preclinical testing with potential for greater translatability to clinical applications. However, the presence of both mouse and human cells that respond to TLR ligands poses a...

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Detalles Bibliográficos
Autores principales:	Twomey, Rachel, Graham, Sean, Spina, Joseph S., Wu, Xiaoming, Dubé, Philip E., Ferrebee, Courtney, Housley, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Journal of Biological Methods 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691501/ https://www.ncbi.nlm.nih.gov/pubmed/38046987 http://dx.doi.org/10.14440/jbm.2023.408

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