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Cleavage of periostin by MMP9 protects mice from kidney cystic disease
The matrix metalloproteinase MMP9 influences cellular morphology and function, and plays important roles in organogenesis and disease. It exerts both protective and deleterious effects in renal pathology, depending upon its specific substrates. To explore new functions for MMP9 in kidney cysts forma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691688/ https://www.ncbi.nlm.nih.gov/pubmed/38039285 http://dx.doi.org/10.1371/journal.pone.0294922 |
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author | Djaziri, Nabila Burel, Cindy Abbad, Lilia Bakey, Zeineb Piedagnel, Rémi Lelongt, Brigitte |
author_facet | Djaziri, Nabila Burel, Cindy Abbad, Lilia Bakey, Zeineb Piedagnel, Rémi Lelongt, Brigitte |
author_sort | Djaziri, Nabila |
collection | PubMed |
description | The matrix metalloproteinase MMP9 influences cellular morphology and function, and plays important roles in organogenesis and disease. It exerts both protective and deleterious effects in renal pathology, depending upon its specific substrates. To explore new functions for MMP9 in kidney cysts formation and disease progression, we generated a mouse model by breeding juvenile cystic kidney (jck) mice with MMP9 deficient mice. Specifically, we provide evidence that MMP9 is overexpressed in cystic tissue where its enzymatic activity is increased 7-fold. MMP9 deficiency in cystic kidney worsen cystic kidney diseases by decreasing renal function, favoring cyst expansion and fibrosis. In addition, we find that periostin is a new critical substrate for MMP9 and in its absence periostin accumulates in cystic lining cells. As periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney diseases, we propose that the control of periostin by MMP9 and its associated intracellular signaling pathways including integrins, integrin-linked kinase and focal adhesion kinase confers to MMP9 a protective effect on the severity of the disease. |
format | Online Article Text |
id | pubmed-10691688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106916882023-12-02 Cleavage of periostin by MMP9 protects mice from kidney cystic disease Djaziri, Nabila Burel, Cindy Abbad, Lilia Bakey, Zeineb Piedagnel, Rémi Lelongt, Brigitte PLoS One Research Article The matrix metalloproteinase MMP9 influences cellular morphology and function, and plays important roles in organogenesis and disease. It exerts both protective and deleterious effects in renal pathology, depending upon its specific substrates. To explore new functions for MMP9 in kidney cysts formation and disease progression, we generated a mouse model by breeding juvenile cystic kidney (jck) mice with MMP9 deficient mice. Specifically, we provide evidence that MMP9 is overexpressed in cystic tissue where its enzymatic activity is increased 7-fold. MMP9 deficiency in cystic kidney worsen cystic kidney diseases by decreasing renal function, favoring cyst expansion and fibrosis. In addition, we find that periostin is a new critical substrate for MMP9 and in its absence periostin accumulates in cystic lining cells. As periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney diseases, we propose that the control of periostin by MMP9 and its associated intracellular signaling pathways including integrins, integrin-linked kinase and focal adhesion kinase confers to MMP9 a protective effect on the severity of the disease. Public Library of Science 2023-12-01 /pmc/articles/PMC10691688/ /pubmed/38039285 http://dx.doi.org/10.1371/journal.pone.0294922 Text en © 2023 Djaziri et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Djaziri, Nabila Burel, Cindy Abbad, Lilia Bakey, Zeineb Piedagnel, Rémi Lelongt, Brigitte Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title | Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title_full | Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title_fullStr | Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title_full_unstemmed | Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title_short | Cleavage of periostin by MMP9 protects mice from kidney cystic disease |
title_sort | cleavage of periostin by mmp9 protects mice from kidney cystic disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691688/ https://www.ncbi.nlm.nih.gov/pubmed/38039285 http://dx.doi.org/10.1371/journal.pone.0294922 |
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