EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors

The efficacy of CAR-T cells for solid tumors is unsatisfactory. EpCAM is a biomarker of epithelial tumors, but the clinical feasibility of CAR-T therapy targeting EpCAM is lacking. Here, we report pre- and clinical investigations of EpCAM–CAR-T cells for solid tumors. We demonstrated that EpCAM–CAR-...

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Detalles Bibliográficos
Autores principales: Li, Dan, Guo, Xianling, Yang, Kun, Yang, Yuening, Zhou, Weilin, Huang, Yong, Liang, Xiao, Su, Jinhua, Jiang, Lin, Li, Jing, Fu, Maorong, He, Haixia, Yang, Jinrong, Shi, Huashan, Yang, Hanshuo, Tong, Aiping, Chen, Nianyong, Hu, Jiankun, Xu, Qing, Wei, Yu-Quan, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691766/
https://www.ncbi.nlm.nih.gov/pubmed/38039357
http://dx.doi.org/10.1126/sciadv.adg9721

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