Genetically engineered transfusable platelets using mRNA lipid nanoparticles

Platelet transfusions are essential for managing bleeding and hemostatic dysfunction and could be expanded as a cell therapy due to the multifunctional role of platelets in various diseases. Creating these cell therapies will require modifying transfusable donor platelets to express therapeutic prot...

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Detalles Bibliográficos
Autores principales: Leung, Jerry, Strong, Colton, Badior, Katherine E., Robertson, Madelaine, Wu, Xiaowu, Meledeo, Michael A., Kang, Emma, Paul, Manoj, Sato, Yusuke, Harashima, Hideyoshi, Cap, Andrew P., Devine, Dana V., Jan, Eric, Cullis, Pieter R., Kastrup, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691771/
https://www.ncbi.nlm.nih.gov/pubmed/38039367
http://dx.doi.org/10.1126/sciadv.adi0508

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