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Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learnin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691773/ https://www.ncbi.nlm.nih.gov/pubmed/38039368 http://dx.doi.org/10.1126/sciadv.adi4927 |
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author | Sands, L. Paul Jiang, Angela Liebenow, Brittany DiMarco, Emily Laxton, Adrian W. Tatter, Stephen B. Montague, P. Read Kishida, Kenneth T. |
author_facet | Sands, L. Paul Jiang, Angela Liebenow, Brittany DiMarco, Emily Laxton, Adrian W. Tatter, Stephen B. Montague, P. Read Kishida, Kenneth T. |
author_sort | Sands, L. Paul |
collection | PubMed |
description | In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learning) has limited direct evidence in humans. We report intracranial, subsecond measurements of dopamine release in human striatum measured, while volunteers (i.e., patients undergoing deep brain stimulation surgery) performed a probabilistic reward and punishment learning choice task designed to test whether dopamine release encodes only reward prediction errors or whether dopamine release may also encode adaptive punishment learning signals. Results demonstrate that extracellular dopamine levels can encode both reward and punishment prediction errors within distinct time intervals via independent valence-specific pathways in the human brain. |
format | Online Article Text |
id | pubmed-10691773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106917732023-12-02 Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans Sands, L. Paul Jiang, Angela Liebenow, Brittany DiMarco, Emily Laxton, Adrian W. Tatter, Stephen B. Montague, P. Read Kishida, Kenneth T. Sci Adv Neuroscience In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learning) has limited direct evidence in humans. We report intracranial, subsecond measurements of dopamine release in human striatum measured, while volunteers (i.e., patients undergoing deep brain stimulation surgery) performed a probabilistic reward and punishment learning choice task designed to test whether dopamine release encodes only reward prediction errors or whether dopamine release may also encode adaptive punishment learning signals. Results demonstrate that extracellular dopamine levels can encode both reward and punishment prediction errors within distinct time intervals via independent valence-specific pathways in the human brain. American Association for the Advancement of Science 2023-12-01 /pmc/articles/PMC10691773/ /pubmed/38039368 http://dx.doi.org/10.1126/sciadv.adi4927 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Neuroscience Sands, L. Paul Jiang, Angela Liebenow, Brittany DiMarco, Emily Laxton, Adrian W. Tatter, Stephen B. Montague, P. Read Kishida, Kenneth T. Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title | Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title_full | Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title_fullStr | Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title_full_unstemmed | Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title_short | Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
title_sort | subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691773/ https://www.ncbi.nlm.nih.gov/pubmed/38039368 http://dx.doi.org/10.1126/sciadv.adi4927 |
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