Cargando…

Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans

In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learnin...

Descripción completa

Detalles Bibliográficos
Autores principales: Sands, L. Paul, Jiang, Angela, Liebenow, Brittany, DiMarco, Emily, Laxton, Adrian W., Tatter, Stephen B., Montague, P. Read, Kishida, Kenneth T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691773/
https://www.ncbi.nlm.nih.gov/pubmed/38039368
http://dx.doi.org/10.1126/sciadv.adi4927
_version_ 1785152806693371904
author Sands, L. Paul
Jiang, Angela
Liebenow, Brittany
DiMarco, Emily
Laxton, Adrian W.
Tatter, Stephen B.
Montague, P. Read
Kishida, Kenneth T.
author_facet Sands, L. Paul
Jiang, Angela
Liebenow, Brittany
DiMarco, Emily
Laxton, Adrian W.
Tatter, Stephen B.
Montague, P. Read
Kishida, Kenneth T.
author_sort Sands, L. Paul
collection PubMed
description In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learning) has limited direct evidence in humans. We report intracranial, subsecond measurements of dopamine release in human striatum measured, while volunteers (i.e., patients undergoing deep brain stimulation surgery) performed a probabilistic reward and punishment learning choice task designed to test whether dopamine release encodes only reward prediction errors or whether dopamine release may also encode adaptive punishment learning signals. Results demonstrate that extracellular dopamine levels can encode both reward and punishment prediction errors within distinct time intervals via independent valence-specific pathways in the human brain.
format Online
Article
Text
id pubmed-10691773
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-106917732023-12-02 Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans Sands, L. Paul Jiang, Angela Liebenow, Brittany DiMarco, Emily Laxton, Adrian W. Tatter, Stephen B. Montague, P. Read Kishida, Kenneth T. Sci Adv Neuroscience In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. This hypothesis (and alternatives regarding dopamine’s role in punishment-learning) has limited direct evidence in humans. We report intracranial, subsecond measurements of dopamine release in human striatum measured, while volunteers (i.e., patients undergoing deep brain stimulation surgery) performed a probabilistic reward and punishment learning choice task designed to test whether dopamine release encodes only reward prediction errors or whether dopamine release may also encode adaptive punishment learning signals. Results demonstrate that extracellular dopamine levels can encode both reward and punishment prediction errors within distinct time intervals via independent valence-specific pathways in the human brain. American Association for the Advancement of Science 2023-12-01 /pmc/articles/PMC10691773/ /pubmed/38039368 http://dx.doi.org/10.1126/sciadv.adi4927 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Sands, L. Paul
Jiang, Angela
Liebenow, Brittany
DiMarco, Emily
Laxton, Adrian W.
Tatter, Stephen B.
Montague, P. Read
Kishida, Kenneth T.
Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title_full Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title_fullStr Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title_full_unstemmed Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title_short Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
title_sort subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691773/
https://www.ncbi.nlm.nih.gov/pubmed/38039368
http://dx.doi.org/10.1126/sciadv.adi4927
work_keys_str_mv AT sandslpaul subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT jiangangela subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT liebenowbrittany subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT dimarcoemily subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT laxtonadrianw subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT tatterstephenb subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT montaguepread subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans
AT kishidakennetht subsecondfluctuationsinextracellulardopamineencoderewardandpunishmentpredictionerrorsinhumans