Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling

Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading to the hypothesis that excess Gαq signaling within the syncytiotrophoblas...

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Detalles Bibliográficos
Autores principales: Opichka, Megan A., Livergood, M. Christine, Balapattabi, Kirthikaa, Ritter, McKenzie L., Brozoski, Daniel T., Wackman, Kelsey K., Lu, Ko-Ting, Kozak, Kaleigh N., Wells, Clive, Fogo, Agnes B., Gibson-Corley, Katherine N., Kwitek, Anne E., Sigmund, Curt D., McIntosh, Jennifer J., Grobe, Justin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691776/
https://www.ncbi.nlm.nih.gov/pubmed/38039359
http://dx.doi.org/10.1126/sciadv.adg8118

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