Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance

Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. While emerging evidence suggests that CSCs have a unique dependency on lipid metabolism, the functions and regulation of distinct lipid species in CSCs remain poorly understood. Here, we developed a stem cell factor SOX9-b...

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Detalles Bibliográficos
Autores principales: Cui, Jihong, Christin, John R., Reisz, Julie A., Cendali, Francesca Isabelle, Sanawar, Rahul, Coutinho De Miranda, Marcelo, D’Alessandro, Angelo, Guo, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691781/
https://www.ncbi.nlm.nih.gov/pubmed/38039374
http://dx.doi.org/10.1126/sciadv.adh1891

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