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X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner

In light of the growing interest in-vivo deuterium metabolic imaging, hyperpolarized (13)C, (15)N, (3)He, and (129)Xe imaging, as well as (31)P spectroscopy and imaging in large animals on clinical MR scanners, we demonstrate the use of a (radio)frequency converter system to allow X-nuclear MR spect...

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Autores principales: Yen, Yi-Fen, Takahashi, Atsushi M., Ackerman, Jerome L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691785/
https://www.ncbi.nlm.nih.gov/pubmed/38046796
http://dx.doi.org/10.1016/j.jmro.2023.100118
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author Yen, Yi-Fen
Takahashi, Atsushi M.
Ackerman, Jerome L.
author_facet Yen, Yi-Fen
Takahashi, Atsushi M.
Ackerman, Jerome L.
author_sort Yen, Yi-Fen
collection PubMed
description In light of the growing interest in-vivo deuterium metabolic imaging, hyperpolarized (13)C, (15)N, (3)He, and (129)Xe imaging, as well as (31)P spectroscopy and imaging in large animals on clinical MR scanners, we demonstrate the use of a (radio)frequency converter system to allow X-nuclear MR spectroscopy (MRS) and MR imaging (MRI) on standard clinical MRI scanners without multinuclear capability. This is not only an economical alternative to the multinuclear system (MNS) provided by the scanner vendors, but also overcomes the frequency bandwidth problem of some vendor-provided MNSs that prohibit users from applications with X-nuclei of low magnetogyric ratio, such as deuterium (6.536 MHz/Tesla) and (15)N (−4.316 MHz/Tesla). Here we illustrate the design of the frequency converter system and demonstrate its feasibility for (31)P (17.235 MHz/Tesla), (13)C (10.708 MHz/Tesla), and (15)N MRS and MRI on a clinical MRI scanner without vendor-provided multinuclear hardware.
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spelling pubmed-106917852023-12-01 X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner Yen, Yi-Fen Takahashi, Atsushi M. Ackerman, Jerome L. J Magn Reson Open Article In light of the growing interest in-vivo deuterium metabolic imaging, hyperpolarized (13)C, (15)N, (3)He, and (129)Xe imaging, as well as (31)P spectroscopy and imaging in large animals on clinical MR scanners, we demonstrate the use of a (radio)frequency converter system to allow X-nuclear MR spectroscopy (MRS) and MR imaging (MRI) on standard clinical MRI scanners without multinuclear capability. This is not only an economical alternative to the multinuclear system (MNS) provided by the scanner vendors, but also overcomes the frequency bandwidth problem of some vendor-provided MNSs that prohibit users from applications with X-nuclei of low magnetogyric ratio, such as deuterium (6.536 MHz/Tesla) and (15)N (−4.316 MHz/Tesla). Here we illustrate the design of the frequency converter system and demonstrate its feasibility for (31)P (17.235 MHz/Tesla), (13)C (10.708 MHz/Tesla), and (15)N MRS and MRI on a clinical MRI scanner without vendor-provided multinuclear hardware. 2023-12 2023-04-24 /pmc/articles/PMC10691785/ /pubmed/38046796 http://dx.doi.org/10.1016/j.jmro.2023.100118 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Yen, Yi-Fen
Takahashi, Atsushi M.
Ackerman, Jerome L.
X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title_full X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title_fullStr X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title_full_unstemmed X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title_short X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner
title_sort x-nuclear mrs and mri on a standard clinical proton-only mri scanner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691785/
https://www.ncbi.nlm.nih.gov/pubmed/38046796
http://dx.doi.org/10.1016/j.jmro.2023.100118
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