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Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review

One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective o...

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Autores principales: Salazar Flórez, Jorge Emilio, Segura Cardona, Ángela María, Restrepo Jaramillo, Berta Nelly, Arboleda Naranjo, Margarita, Giraldo Cardona, Luz Stella, Echeverri Rendón, Ángela Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical de São Paulo 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691806/
http://dx.doi.org/10.1590/S1678-9946202365058
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author Salazar Flórez, Jorge Emilio
Segura Cardona, Ángela María
Restrepo Jaramillo, Berta Nelly
Arboleda Naranjo, Margarita
Giraldo Cardona, Luz Stella
Echeverri Rendón, Ángela Patricia
author_facet Salazar Flórez, Jorge Emilio
Segura Cardona, Ángela María
Restrepo Jaramillo, Berta Nelly
Arboleda Naranjo, Margarita
Giraldo Cardona, Luz Stella
Echeverri Rendón, Ángela Patricia
author_sort Salazar Flórez, Jorge Emilio
collection PubMed
description One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area. Case-control studies conducted in Latin American countries examining at least one form of genetic polymorphism related to immune responses against severe dengue were included. In total, 424 articles were identified and 26 were included in this systematic review. Of the 26 selected articles, 16 reported polymorphisms associated with the risk of developing severe dengue (Risk); Similarly, 16 articles reported polymorphisms associated with a decreased risk of severe dengue (Protective). The final analysis revealed that multiple polymorphisms in immune system genes were early markers of the progression of dengue in Latin Americans and found that polymorphisms of the TNF-alpha gene may have a critical role in dengue pathogenesis.
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spelling pubmed-106918062023-12-02 Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review Salazar Flórez, Jorge Emilio Segura Cardona, Ángela María Restrepo Jaramillo, Berta Nelly Arboleda Naranjo, Margarita Giraldo Cardona, Luz Stella Echeverri Rendón, Ángela Patricia Rev Inst Med Trop Sao Paulo Review One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area. Case-control studies conducted in Latin American countries examining at least one form of genetic polymorphism related to immune responses against severe dengue were included. In total, 424 articles were identified and 26 were included in this systematic review. Of the 26 selected articles, 16 reported polymorphisms associated with the risk of developing severe dengue (Risk); Similarly, 16 articles reported polymorphisms associated with a decreased risk of severe dengue (Protective). The final analysis revealed that multiple polymorphisms in immune system genes were early markers of the progression of dengue in Latin Americans and found that polymorphisms of the TNF-alpha gene may have a critical role in dengue pathogenesis. Instituto de Medicina Tropical de São Paulo 2023-12-01 /pmc/articles/PMC10691806/ http://dx.doi.org/10.1590/S1678-9946202365058 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Salazar Flórez, Jorge Emilio
Segura Cardona, Ángela María
Restrepo Jaramillo, Berta Nelly
Arboleda Naranjo, Margarita
Giraldo Cardona, Luz Stella
Echeverri Rendón, Ángela Patricia
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title_full Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title_fullStr Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title_full_unstemmed Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title_short Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
title_sort immune system gene polymorphisms associated with severe dengue in latin america: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691806/
http://dx.doi.org/10.1590/S1678-9946202365058
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