A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

The testis is pivotal for male reproduction, and its progressive functional decline in aging is associated with infertility. However, the regulatory mechanism underlying primate testicular aging remains largely elusive. Here, we resolve the aging-related cellular and molecular alterations of primate...

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Detalles Bibliográficos
Autores principales: Huang, Daoyuan, Zuo, Yuesheng, Zhang, Chen, Sun, Guoqiang, Jing, Ying, Lei, Jinghui, Ma, Shuai, Sun, Shuhui, Lu, Huifen, Cai, Yusheng, Zhang, Weiqi, Gao, Fei, Peng Xiang, Andy, Belmonte, Juan Carlos Izpisua, Liu, Guang-Hui, Qu, Jing, Wang, Si
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691849/
https://www.ncbi.nlm.nih.gov/pubmed/36929025
http://dx.doi.org/10.1093/procel/pwac057

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