Cargando…

Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis

Cystic hypersecretory carcinoma (CHC) is a rare subset of in-situ breast carcinoma with or without associated invasive carcinoma. It is part of a spectrum of cystic hypersecretory lesions that includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ, and CHC with invasion. Only...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhandapani, Karthik, Shah, Ashini, Kapoor, Shilpa, Gandhi, Jahnavi, Thayakaran, Immanuel Paul, Trivedi, Priti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691907/
https://www.ncbi.nlm.nih.gov/pubmed/38047046
http://dx.doi.org/10.1055/s-0043-1768629
_version_ 1785152827619803136
author Dhandapani, Karthik
Shah, Ashini
Kapoor, Shilpa
Gandhi, Jahnavi
Thayakaran, Immanuel Paul
Trivedi, Priti
author_facet Dhandapani, Karthik
Shah, Ashini
Kapoor, Shilpa
Gandhi, Jahnavi
Thayakaran, Immanuel Paul
Trivedi, Priti
author_sort Dhandapani, Karthik
collection PubMed
description Cystic hypersecretory carcinoma (CHC) is a rare subset of in-situ breast carcinoma with or without associated invasive carcinoma. It is part of a spectrum of cystic hypersecretory lesions that includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ, and CHC with invasion. Only 20 cases of CHC with invasion have been reported so far. A 60-year-old female presented with a palpable right breast mass. A core needle biopsy was carried out, which was reported as invasive breast carcinoma with areas of ductal carcinoma in situ (DCIS). Modified radical mastectomy was done post-neo-adjuvant chemotherapy; On microscopy, dilated cystic spaces filled with eosinophilic secretions (thyroid colloid-like), lining neoplastic cells with variable degrees of proliferation and atypia were seen. There were multiple foci of invasion; both skin invasion and axillary lymph node metastasis were present. Immunohistochemistry (IHC) was done with relevant markers; correlating all these findings, a diagnosis of CHC with invasion was made. CHC is a distinct form of DCIS with or without associated invasion. Awareness of this entity is required to rule out other differential diagnoses and to avoid misinterpretation. Little is known about the IHC profile, biological behavior, prognosis, and molecular profile of CHC due to its rarity.
format Online
Article
Text
id pubmed-10691907
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-106919072023-12-02 Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis Dhandapani, Karthik Shah, Ashini Kapoor, Shilpa Gandhi, Jahnavi Thayakaran, Immanuel Paul Trivedi, Priti South Asian J Cancer Cystic hypersecretory carcinoma (CHC) is a rare subset of in-situ breast carcinoma with or without associated invasive carcinoma. It is part of a spectrum of cystic hypersecretory lesions that includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ, and CHC with invasion. Only 20 cases of CHC with invasion have been reported so far. A 60-year-old female presented with a palpable right breast mass. A core needle biopsy was carried out, which was reported as invasive breast carcinoma with areas of ductal carcinoma in situ (DCIS). Modified radical mastectomy was done post-neo-adjuvant chemotherapy; On microscopy, dilated cystic spaces filled with eosinophilic secretions (thyroid colloid-like), lining neoplastic cells with variable degrees of proliferation and atypia were seen. There were multiple foci of invasion; both skin invasion and axillary lymph node metastasis were present. Immunohistochemistry (IHC) was done with relevant markers; correlating all these findings, a diagnosis of CHC with invasion was made. CHC is a distinct form of DCIS with or without associated invasion. Awareness of this entity is required to rule out other differential diagnoses and to avoid misinterpretation. Little is known about the IHC profile, biological behavior, prognosis, and molecular profile of CHC due to its rarity. Thieme Medical and Scientific Publishers Pvt. Ltd. 2023-08-12 /pmc/articles/PMC10691907/ /pubmed/38047046 http://dx.doi.org/10.1055/s-0043-1768629 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Dhandapani, Karthik
Shah, Ashini
Kapoor, Shilpa
Gandhi, Jahnavi
Thayakaran, Immanuel Paul
Trivedi, Priti
Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title_full Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title_fullStr Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title_full_unstemmed Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title_short Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis
title_sort cystic hypersecretory carcinoma of the breast: a rare case report with review of literature and emphasis on differential diagnosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691907/
https://www.ncbi.nlm.nih.gov/pubmed/38047046
http://dx.doi.org/10.1055/s-0043-1768629
work_keys_str_mv AT dhandapanikarthik cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis
AT shahashini cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis
AT kapoorshilpa cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis
AT gandhijahnavi cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis
AT thayakaranimmanuelpaul cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis
AT trivedipriti cystichypersecretorycarcinomaofthebreastararecasereportwithreviewofliteratureandemphasisondifferentialdiagnosis