TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis

The long non-coding RNA (lncRNA) TMEM44-AS1 is a novel lncRNA whose pro-carcinogenic role in gastric cancer and glioma has been demonstrated. However, its function in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we identified that TMEM44-AS1 was highly expressed in ESCC tissu...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ruotong, Wan, Junhu, Ma, Liwei, Zhou, Fuyou, Yang, Zhengwu, Li, Zhuofang, Zhang, Mingyuan, Ming, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692126/
https://www.ncbi.nlm.nih.gov/pubmed/38040698
http://dx.doi.org/10.1038/s41420-023-01727-0
_version_ 1785152874644242432
author Yang, Ruotong
Wan, Junhu
Ma, Liwei
Zhou, Fuyou
Yang, Zhengwu
Li, Zhuofang
Zhang, Mingyuan
Ming, Liang
author_facet Yang, Ruotong
Wan, Junhu
Ma, Liwei
Zhou, Fuyou
Yang, Zhengwu
Li, Zhuofang
Zhang, Mingyuan
Ming, Liang
author_sort Yang, Ruotong
collection PubMed
description The long non-coding RNA (lncRNA) TMEM44-AS1 is a novel lncRNA whose pro-carcinogenic role in gastric cancer and glioma has been demonstrated. However, its function in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we identified that TMEM44-AS1 was highly expressed in ESCC tissues and cells. Functionally, TMEM44-AS1 promoted ESCC cell proliferation, invasion and metastasis in vitro and in vivo. TMEM44-AS1 inhibited ferroptosis in ESCC cells, and ferroptosis levels were significantly increased after knockdown of TMEM44-AS1. Mechanistically, TMEM44-AS1 was positively correlated with GPX4 expression, and TMEM44-AS1 could bind to the RNA-binding protein IGF2BP2 to enhance the stability of GPX4 mRNA, thereby affecting ferroptosis and regulating the malignant progression of ESCC. In summary, this study reveals the TMEM44-AS1-IGF2BP2-GPX4 axis could influence cancer progression in ESCC. TMEM44-AS1 can be used as a potential treatment target against ESCC.
format Online
Article
Text
id pubmed-10692126
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-106921262023-12-03 TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis Yang, Ruotong Wan, Junhu Ma, Liwei Zhou, Fuyou Yang, Zhengwu Li, Zhuofang Zhang, Mingyuan Ming, Liang Cell Death Discov Article The long non-coding RNA (lncRNA) TMEM44-AS1 is a novel lncRNA whose pro-carcinogenic role in gastric cancer and glioma has been demonstrated. However, its function in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we identified that TMEM44-AS1 was highly expressed in ESCC tissues and cells. Functionally, TMEM44-AS1 promoted ESCC cell proliferation, invasion and metastasis in vitro and in vivo. TMEM44-AS1 inhibited ferroptosis in ESCC cells, and ferroptosis levels were significantly increased after knockdown of TMEM44-AS1. Mechanistically, TMEM44-AS1 was positively correlated with GPX4 expression, and TMEM44-AS1 could bind to the RNA-binding protein IGF2BP2 to enhance the stability of GPX4 mRNA, thereby affecting ferroptosis and regulating the malignant progression of ESCC. In summary, this study reveals the TMEM44-AS1-IGF2BP2-GPX4 axis could influence cancer progression in ESCC. TMEM44-AS1 can be used as a potential treatment target against ESCC. Nature Publishing Group UK 2023-12-01 /pmc/articles/PMC10692126/ /pubmed/38040698 http://dx.doi.org/10.1038/s41420-023-01727-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Ruotong
Wan, Junhu
Ma, Liwei
Zhou, Fuyou
Yang, Zhengwu
Li, Zhuofang
Zhang, Mingyuan
Ming, Liang
TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title_full TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title_fullStr TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title_full_unstemmed TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title_short TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis
title_sort tmem44-as1 promotes esophageal squamous cell carcinoma progression by regulating the igf2bp2-gpx4 axis in modulating ferroptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692126/
https://www.ncbi.nlm.nih.gov/pubmed/38040698
http://dx.doi.org/10.1038/s41420-023-01727-0
work_keys_str_mv AT yangruotong tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT wanjunhu tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT maliwei tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT zhoufuyou tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT yangzhengwu tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT lizhuofang tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT zhangmingyuan tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis
AT mingliang tmem44as1promotesesophagealsquamouscellcarcinomaprogressionbyregulatingtheigf2bp2gpx4axisinmodulatingferroptosis

Ejemplares similares