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Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains

P-glycoprotein (P-gp), a membrane transport protein overexpressed in certain drug-resistant cancer cells, has been the target of numerous drug discovery projects aimed at overcoming drug resistance in cancer. Most characterized P-gp inhibitors bind at the large hydrophobic drug binding domain (DBD),...

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Detalles Bibliográficos
Autores principales:	Moesgaard, Laust, Pedersen, Maria L., Uhd Nielsen, Carsten, Kongsted, Jacob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692163/ https://www.ncbi.nlm.nih.gov/pubmed/38040777 http://dx.doi.org/10.1038/s41598-023-48281-4

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