Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8

The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive therapeutic approach, but the molecular basis for chemokine-mediated activation and antibod...

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Detalles Bibliográficos
Autores principales: Sun, Dawei, Sun, Yonglian, Janezic, Eric, Zhou, Tricia, Johnson, Matthew, Azumaya, Caleigh, Noreng, Sigrid, Chiu, Cecilia, Seki, Akiko, Arenzana, Teresita L., Nicoludis, John M., Shi, Yongchang, Wang, Baomei, Ho, Hoangdung, Joshi, Prajakta, Tam, Christine, Payandeh, Jian, Comps-Agrar, Laëtitia, Wang, Jianyong, Rutz, Sascha, Koerber, James T., Masureel, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692165/
https://www.ncbi.nlm.nih.gov/pubmed/38040762
http://dx.doi.org/10.1038/s41467-023-43601-8

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