Cargando…

Music compensates for altered gene expression in age-related cognitive disorders

Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Gómez-Carballa, Alberto, Navarro, Laura, Pardo-Seco, Jacobo, Bello, Xabier, Pischedda, Sara, Viz-Lasheras, Sandra, Camino-Mera, Alba, Currás, María José, Ferreirós, Isabel, Mallah, Narmeen, Rey-Vázquez, Sara, Redondo, Lorenzo, Dacosta-Urbieta, Ana, Caamaño-Viña, Fernando, Rivero-Calle, Irene, Rodriguez-Tenreiro, Carmen, Martinón-Torres, Federico, Salas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692168/
https://www.ncbi.nlm.nih.gov/pubmed/38040763
http://dx.doi.org/10.1038/s41598-023-48094-5
_version_ 1785152884001734656
author Gómez-Carballa, Alberto
Navarro, Laura
Pardo-Seco, Jacobo
Bello, Xabier
Pischedda, Sara
Viz-Lasheras, Sandra
Camino-Mera, Alba
Currás, María José
Ferreirós, Isabel
Mallah, Narmeen
Rey-Vázquez, Sara
Redondo, Lorenzo
Dacosta-Urbieta, Ana
Caamaño-Viña, Fernando
Rivero-Calle, Irene
Rodriguez-Tenreiro, Carmen
Martinón-Torres, Federico
Salas, Antonio
author_facet Gómez-Carballa, Alberto
Navarro, Laura
Pardo-Seco, Jacobo
Bello, Xabier
Pischedda, Sara
Viz-Lasheras, Sandra
Camino-Mera, Alba
Currás, María José
Ferreirós, Isabel
Mallah, Narmeen
Rey-Vázquez, Sara
Redondo, Lorenzo
Dacosta-Urbieta, Ana
Caamaño-Viña, Fernando
Rivero-Calle, Irene
Rodriguez-Tenreiro, Carmen
Martinón-Torres, Federico
Salas, Antonio
author_sort Gómez-Carballa, Alberto
collection PubMed
description Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.
format Online
Article
Text
id pubmed-10692168
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-106921682023-12-03 Music compensates for altered gene expression in age-related cognitive disorders Gómez-Carballa, Alberto Navarro, Laura Pardo-Seco, Jacobo Bello, Xabier Pischedda, Sara Viz-Lasheras, Sandra Camino-Mera, Alba Currás, María José Ferreirós, Isabel Mallah, Narmeen Rey-Vázquez, Sara Redondo, Lorenzo Dacosta-Urbieta, Ana Caamaño-Viña, Fernando Rivero-Calle, Irene Rodriguez-Tenreiro, Carmen Martinón-Torres, Federico Salas, Antonio Sci Rep Article Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders. Nature Publishing Group UK 2023-12-02 /pmc/articles/PMC10692168/ /pubmed/38040763 http://dx.doi.org/10.1038/s41598-023-48094-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gómez-Carballa, Alberto
Navarro, Laura
Pardo-Seco, Jacobo
Bello, Xabier
Pischedda, Sara
Viz-Lasheras, Sandra
Camino-Mera, Alba
Currás, María José
Ferreirós, Isabel
Mallah, Narmeen
Rey-Vázquez, Sara
Redondo, Lorenzo
Dacosta-Urbieta, Ana
Caamaño-Viña, Fernando
Rivero-Calle, Irene
Rodriguez-Tenreiro, Carmen
Martinón-Torres, Federico
Salas, Antonio
Music compensates for altered gene expression in age-related cognitive disorders
title Music compensates for altered gene expression in age-related cognitive disorders
title_full Music compensates for altered gene expression in age-related cognitive disorders
title_fullStr Music compensates for altered gene expression in age-related cognitive disorders
title_full_unstemmed Music compensates for altered gene expression in age-related cognitive disorders
title_short Music compensates for altered gene expression in age-related cognitive disorders
title_sort music compensates for altered gene expression in age-related cognitive disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692168/
https://www.ncbi.nlm.nih.gov/pubmed/38040763
http://dx.doi.org/10.1038/s41598-023-48094-5
work_keys_str_mv AT gomezcarballaalberto musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT navarrolaura musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT pardosecojacobo musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT belloxabier musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT pischeddasara musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT vizlasherassandra musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT caminomeraalba musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT currasmariajose musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT ferreirosisabel musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT mallahnarmeen musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT reyvazquezsara musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT redondolorenzo musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT dacostaurbietaana musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT caamanovinafernando musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT riverocalleirene musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT rodrigueztenreirocarmen musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT martinontorresfederico musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders
AT salasantonio musiccompensatesforalteredgeneexpressioninagerelatedcognitivedisorders