SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors

Malignant rhabdoid tumor (MRT) is a highly malignant and often lethal childhood cancer. MRTs are genetically defined by bi-allelic inactivating mutations in SMARCB1, a member of the BRG1/BRM-associated factors (BAF) chromatin remodeling complex. Mutations in BAF complex members are common in human c...

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Detalles Bibliográficos
Autores principales: Liu, Ning Qing, Paassen, Irene, Custers, Lars, Zeller, Peter, Teunissen, Hans, Ayyildiz, Dilara, He, Jiayou, Buhl, Juliane Laura, Hoving, Eelco Wieger, van Oudenaarden, Alexander, de Wit, Elzo, Drost, Jarno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692191/
https://www.ncbi.nlm.nih.gov/pubmed/38040699
http://dx.doi.org/10.1038/s41467-023-43498-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692191/
https://www.ncbi.nlm.nih.gov/pubmed/38040699
http://dx.doi.org/10.1038/s41467-023-43498-3

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