Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases in the cytosol, the N-terminal domain of GSDMD forms pores in the plasma membr...

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Detalles Bibliográficos
Autores principales: Kopp, Anja, Hagelueken, Gregor, Jamitzky, Isabell, Moecking, Jonas, Schiffelers, Lisa D. J., Schmidt, Florian I., Geyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692205/
https://www.ncbi.nlm.nih.gov/pubmed/38040708
http://dx.doi.org/10.1038/s41467-023-43707-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692205/
https://www.ncbi.nlm.nih.gov/pubmed/38040708
http://dx.doi.org/10.1038/s41467-023-43707-z

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