A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors

Protein arginine methyltransferases (PRMTs) are attractive targets for developing therapeutic agents, but selective PRMT inhibitors targeting the cofactor SAM binding site are limited. Herein, we report the discovery of a noncanonical but less polar SAH surrogate YD1113 by replacing the benzyl guani...

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Detalles Bibliográficos
Autores principales: Deng, Youchao, Song, Xiaosheng, Iyamu, Iredia D., Dong, Aiping, Min, Jinrong, Huang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692381/
https://www.ncbi.nlm.nih.gov/pubmed/38045046
http://dx.doi.org/10.1016/j.apsb.2023.07.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692381/
https://www.ncbi.nlm.nih.gov/pubmed/38045046
http://dx.doi.org/10.1016/j.apsb.2023.07.022

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