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A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
Protein arginine methyltransferases (PRMTs) are attractive targets for developing therapeutic agents, but selective PRMT inhibitors targeting the cofactor SAM binding site are limited. Herein, we report the discovery of a noncanonical but less polar SAH surrogate YD1113 by replacing the benzyl guani...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692381/ https://www.ncbi.nlm.nih.gov/pubmed/38045046 http://dx.doi.org/10.1016/j.apsb.2023.07.022 |