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Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men

OBJECTIVE: This study seeks to determine the association between vitamin D and testosterone in healthy, adult Filipino males. METHODOLOGY: This cross-sectional study included 110 healthy, non-obese, male volunteers aged 21–40. History and physical exam were taken, and blood was drawn for vitamin D,...

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Autores principales: Buenaluz-Sedurante, Myrna, Bruno, Racquel, Dagang, Daryl Jade, Isaiah Co, Mark, Tee, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the ASEAN Federation of Endocrine Societies 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692406/
https://www.ncbi.nlm.nih.gov/pubmed/38045666
http://dx.doi.org/10.15605/jafes.038.02.14
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author Buenaluz-Sedurante, Myrna
Bruno, Racquel
Dagang, Daryl Jade
Isaiah Co, Mark
Tee, Michael
author_facet Buenaluz-Sedurante, Myrna
Bruno, Racquel
Dagang, Daryl Jade
Isaiah Co, Mark
Tee, Michael
author_sort Buenaluz-Sedurante, Myrna
collection PubMed
description OBJECTIVE: This study seeks to determine the association between vitamin D and testosterone in healthy, adult Filipino males. METHODOLOGY: This cross-sectional study included 110 healthy, non-obese, male volunteers aged 21–40. History and physical exam were taken, and blood was drawn for vitamin D, total testosterone (TT), sex hormone binding globulin (SHBG), albumin, insulin, fasting plasma glucose, and total cholesterol. Free testosterone (FT) was calculated. Vitamin D data were classified by status and TT, FT, and SHBG levels compared using the Kruskal–Wallis test. The associations of vitamin D levels with TT, FT, and SHBG were explored using multiple regression analysis. RESULTS: Vitamin D levels were sufficient in 3 (2.7%), insufficient in 17 (15.45%), and deficient in 90 (81.8%) of the sample. There were no significant differences in the mean TT (p = 0.7981), FT (p = 0.8768), nor SHBG (p = 0.1838) across vitamin D status. Vitamin D was not associated with TT nor FT before or after adjustment for age and age plus body mass index (BMI). Vitamin D was associated with SHBG before and after the aforementioned adjustments, but this became insignificant on sensitivity analysis. CONCLUSION: There is no association between vitamin D and TT, FT nor SHBG in our cohort with deficient vitamin D levels.
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spelling pubmed-106924062023-12-03 Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men Buenaluz-Sedurante, Myrna Bruno, Racquel Dagang, Daryl Jade Isaiah Co, Mark Tee, Michael J ASEAN Fed Endocr Soc Original Article OBJECTIVE: This study seeks to determine the association between vitamin D and testosterone in healthy, adult Filipino males. METHODOLOGY: This cross-sectional study included 110 healthy, non-obese, male volunteers aged 21–40. History and physical exam were taken, and blood was drawn for vitamin D, total testosterone (TT), sex hormone binding globulin (SHBG), albumin, insulin, fasting plasma glucose, and total cholesterol. Free testosterone (FT) was calculated. Vitamin D data were classified by status and TT, FT, and SHBG levels compared using the Kruskal–Wallis test. The associations of vitamin D levels with TT, FT, and SHBG were explored using multiple regression analysis. RESULTS: Vitamin D levels were sufficient in 3 (2.7%), insufficient in 17 (15.45%), and deficient in 90 (81.8%) of the sample. There were no significant differences in the mean TT (p = 0.7981), FT (p = 0.8768), nor SHBG (p = 0.1838) across vitamin D status. Vitamin D was not associated with TT nor FT before or after adjustment for age and age plus body mass index (BMI). Vitamin D was associated with SHBG before and after the aforementioned adjustments, but this became insignificant on sensitivity analysis. CONCLUSION: There is no association between vitamin D and TT, FT nor SHBG in our cohort with deficient vitamin D levels. Journal of the ASEAN Federation of Endocrine Societies 2023-06-21 2023 /pmc/articles/PMC10692406/ /pubmed/38045666 http://dx.doi.org/10.15605/jafes.038.02.14 Text en © 2023 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Original Article
Buenaluz-Sedurante, Myrna
Bruno, Racquel
Dagang, Daryl Jade
Isaiah Co, Mark
Tee, Michael
Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title_full Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title_fullStr Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title_full_unstemmed Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title_short Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men
title_sort association between 25-hydroxyvitamin d levels and testosterone in healthy, non-obese, young adult, filipino men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692406/
https://www.ncbi.nlm.nih.gov/pubmed/38045666
http://dx.doi.org/10.15605/jafes.038.02.14
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