Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection

The bacterial ATP-competitive GyrB/ParE subunits of type II topoisomerase are important anti-bacterial targets to treat super drug-resistant bacterial infections. Herein we discovered novel pyrrolamide-type GyrB/ParE inhibitors based on the structural modifications of the candidate AZD5099 that was...

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Detalles Bibliográficos
Autores principales: Zhao, Xintong, Feng, Jing, Zhang, Jie, Han, Zunsheng, Hu, Yuhua, Shao, Hui-Hui, Li, Tianlei, Xia, Jie, Lei, Kangfan, Wang, Weiping, Lai, Fangfang, Lin, Yuan, Liu, Bo, Zhang, Kun, Zhang, Chi, Yang, Qingyun, Luo, Xinyu, Zhang, Hanyilan, Li, Chuang, Zhang, Wenxuan, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692473/
https://www.ncbi.nlm.nih.gov/pubmed/38045053
http://dx.doi.org/10.1016/j.apsb.2023.08.030

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