Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

As a novel and promising antitumor target, AXL plays an important role in tumor growth, metastasis, immunosuppression and drug resistance of various malignancies, which has attracted extensive research interest in recent years. In this study, by employing the structure-based drug design and bioisost...

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Detalles Bibliográficos
Autores principales: Fang, Feifei, Dai, Yang, Wang, Hao, Ji, Yinchun, Liang, Xuewu, Peng, Xia, Li, Jiyuan, Zhao, Yangrong, Li, Chunpu, Wang, Danyi, Li, Yazhou, Zhang, Dong, Zhang, Dan, Geng, Meiyu, Liu, Hong, Ai, Jing, Zhou, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692477/
https://www.ncbi.nlm.nih.gov/pubmed/38045061
http://dx.doi.org/10.1016/j.apsb.2023.10.002

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