TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage

Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response (DDR), although the mechanism(s) involved remains to be elucidated. This study evaluated the potential role of TBC...

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Detalles Bibliográficos
Autores principales: Yu, Wenjun, Xu, Haixia, Sun, Zhe, Du, Yuxin, Sun, Shiqun, Abudureyimu, Miyesaier, Zhang, Mengjiao, Tao, Jun, Ge, Junbo, Ren, Jun, Zhang, Yingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692480/
https://www.ncbi.nlm.nih.gov/pubmed/38045047
http://dx.doi.org/10.1016/j.apsb.2023.09.008

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