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Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia
Objective: To assess the incidence and impact of metabolic acidosis in Indigenous and non-Indigenous patients Design: Retrospective study. Setting: Adult intensive care units (ICUs) from Australia and New Zealand. Participants: Patients aged 16 years or older admitted to an Australian or New Zealand...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692596/ https://www.ncbi.nlm.nih.gov/pubmed/38046846 http://dx.doi.org/10.51893/2022.1.OA2 |
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author | Neto, Ary Serpa Fujii, Tomoko Moore, James Young, Paul J. Peake, Sandra Bailey, Michael Hodgson, Carol Higgins, Alisa M. See, Emily J. Secombe, Paul Russ, Vanessa Campbell, Lewis Young, Meredith Maeda, Mikihiro Pilcher, David Cooper, Jamie Udy, Andrew |
author_facet | Neto, Ary Serpa Fujii, Tomoko Moore, James Young, Paul J. Peake, Sandra Bailey, Michael Hodgson, Carol Higgins, Alisa M. See, Emily J. Secombe, Paul Russ, Vanessa Campbell, Lewis Young, Meredith Maeda, Mikihiro Pilcher, David Cooper, Jamie Udy, Andrew |
author_sort | Neto, Ary Serpa |
collection | PubMed |
description | Objective: To assess the incidence and impact of metabolic acidosis in Indigenous and non-Indigenous patients Design: Retrospective study. Setting: Adult intensive care units (ICUs) from Australia and New Zealand. Participants: Patients aged 16 years or older admitted to an Australian or New Zealand ICU in one of 195 contributing ICUs between January 2019 and December 2020 who had metabolic acidosis, defined as pH < 7.30, base excess (BE) < −4 mEq/L and PaCO(2) ≤ 45 mmHg. Main outcome measures: The primary outcome was the prevalence of metabolic acidosis. Secondary outcomes included ICU length of stay, hospital length of stay, receipt of renal replacement therapy (RRT), major adverse kidney events at 30 days (MAKE30), and hospital mortality. Results: Overall, 248 563 patients underwent analysis, with 11 537 (4.6%) in the Indigenous group and 237 026 (95.4%) in the non-Indigenous group. The prevalence of metabolic acidosis was higher in Indigenous patients (9.3% v 6.1%; P < 0.001). Indigenous patients with metabolic acidosis received RRT more often (28.2% v 22.0%; P < 0.001), but hospital mortality was similar between the groups (25.8% in Indigenous v 25.8% in non-Indigenous; P = 0.971). Conclusions: Critically ill Indigenous ICU patients are more likely to have a metabolic acidosis in the first 24 hours of their ICU admission, and more often received RRT during their ICU admission compared with non-Indigenous patients. However, hospital mortality was similar between the groups. |
format | Online Article Text |
id | pubmed-10692596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106925962023-12-03 Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia Neto, Ary Serpa Fujii, Tomoko Moore, James Young, Paul J. Peake, Sandra Bailey, Michael Hodgson, Carol Higgins, Alisa M. See, Emily J. Secombe, Paul Russ, Vanessa Campbell, Lewis Young, Meredith Maeda, Mikihiro Pilcher, David Cooper, Jamie Udy, Andrew Crit Care Resusc Original Articles Objective: To assess the incidence and impact of metabolic acidosis in Indigenous and non-Indigenous patients Design: Retrospective study. Setting: Adult intensive care units (ICUs) from Australia and New Zealand. Participants: Patients aged 16 years or older admitted to an Australian or New Zealand ICU in one of 195 contributing ICUs between January 2019 and December 2020 who had metabolic acidosis, defined as pH < 7.30, base excess (BE) < −4 mEq/L and PaCO(2) ≤ 45 mmHg. Main outcome measures: The primary outcome was the prevalence of metabolic acidosis. Secondary outcomes included ICU length of stay, hospital length of stay, receipt of renal replacement therapy (RRT), major adverse kidney events at 30 days (MAKE30), and hospital mortality. Results: Overall, 248 563 patients underwent analysis, with 11 537 (4.6%) in the Indigenous group and 237 026 (95.4%) in the non-Indigenous group. The prevalence of metabolic acidosis was higher in Indigenous patients (9.3% v 6.1%; P < 0.001). Indigenous patients with metabolic acidosis received RRT more often (28.2% v 22.0%; P < 0.001), but hospital mortality was similar between the groups (25.8% in Indigenous v 25.8% in non-Indigenous; P = 0.971). Conclusions: Critically ill Indigenous ICU patients are more likely to have a metabolic acidosis in the first 24 hours of their ICU admission, and more often received RRT during their ICU admission compared with non-Indigenous patients. However, hospital mortality was similar between the groups. Elsevier 2023-10-18 /pmc/articles/PMC10692596/ /pubmed/38046846 http://dx.doi.org/10.51893/2022.1.OA2 Text en © 2022 College of Intensive Care Medicine of Australia and New Zealand. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Articles Neto, Ary Serpa Fujii, Tomoko Moore, James Young, Paul J. Peake, Sandra Bailey, Michael Hodgson, Carol Higgins, Alisa M. See, Emily J. Secombe, Paul Russ, Vanessa Campbell, Lewis Young, Meredith Maeda, Mikihiro Pilcher, David Cooper, Jamie Udy, Andrew Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title | Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title_full | Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title_fullStr | Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title_full_unstemmed | Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title_short | Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia |
title_sort | clinical outcomes of indigenous australians and new zealand māori with metabolic acidosis and acidaemia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692596/ https://www.ncbi.nlm.nih.gov/pubmed/38046846 http://dx.doi.org/10.51893/2022.1.OA2 |
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