Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19

Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that the direct interaction of AEC with macrophages mediated by CD95/CD95L or indirect interaction mediated by IL-6 signaling are key steps for the COVID-19 severe acute i...

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Detalles Bibliográficos
Autores principales: Fraga-Silva, Thais F.C., Cipriano, Ualter G., Fumagalli, Marcilio J., Correa, Giseli F., Fuzo, Carlos A., dos-Santos, Douglas, Mestriner, Fabiola L.A.C., Becari, Christiane, Teixeira-Carvalho, Andrea, Coelho-dos-Reis, Jordana, Menegueti, Mayra G., Figueiredo, Luiz T.M., Cunha, Larissa Dias, Martins-Filho, Olindo A., Dias-Baruffi, Marcelo, Auxiliadora-Martins, Maria, Tostes, Rita C., Bonato, Vania L.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692667/
https://www.ncbi.nlm.nih.gov/pubmed/38047070
http://dx.doi.org/10.1016/j.isci.2023.108366

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