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Drug discovery for heart failure targeting myosin-binding protein C

Cardiac MyBP-C (cMyBP-C) interacts with actin and myosin to fine-tune cardiac muscle contractility. Phosphorylation of cMyBP-C, which reduces the binding of cMyBP-C to actin and myosin, is often decreased in patients with heart failure (HF) and is cardioprotective in model systems of HF. Therefore,...

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Detalles Bibliográficos
Autores principales:	Bunch, Thomas A., Guhathakurta, Piyali, Thompson, Andrew R., Lepak, Victoria C., Carter, Anna L., Thomas, Jennifer J., Thomas, David D., Colson, Brett A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692721/ https://www.ncbi.nlm.nih.gov/pubmed/37865311 http://dx.doi.org/10.1016/j.jbc.2023.105369

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