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NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α

Notch regulates the immune and inflammatory response and has been associated with the pathogenesis of osteoarthritis in humans and preclinical models of the disease. Notch2(tm1.1Ecan) mice harbor a NOTCH2 gain-of-function and are sensitized to osteoarthritis, but the mechanisms have not been explore...

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Detalles Bibliográficos
Autores principales:	Canalis, Ernesto, Yu, Jungeun, Singh, Vijender, Mocarska, Magda, Schilling, Lauren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692730/ https://www.ncbi.nlm.nih.gov/pubmed/37865314 http://dx.doi.org/10.1016/j.jbc.2023.105372

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