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Improving the filtering of false positive single nucleotide variations by combining genomic features with quality metrics
MOTIVATION: Technical errors in sequencing or bioinformatics steps and difficulties in alignment at some genomic sites result in false positive (FP) variants. Filtering based on quality metrics is a common method for detecting FP variants, but setting thresholds to reduce FP rates may reduce the num...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692869/ https://www.ncbi.nlm.nih.gov/pubmed/38019945 http://dx.doi.org/10.1093/bioinformatics/btad694 |