RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay

BACKGROUND: CFTR nonsense alleles generate negligible CFTR protein due to the nonsense mutation: 1) triggering CFTR mRNA degradation by nonsense-mediated mRNA decay (NMD), and 2) terminating CFTR mRNA translation prematurely. Thus, people with cystic fibrosis (PwCF) who carry nonsense alleles cannot...

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Detalles Bibliográficos
Autores principales: Siddiqui, Amna, Saxena, Arpit, Echols, Joshua, Havasi, Viktoria, Fu, Lianwu, Keeling, Kim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692906/
https://www.ncbi.nlm.nih.gov/pubmed/38045134
http://dx.doi.org/10.1016/j.heliyon.2023.e22281

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