IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growth

OBJECTIVE: Tumor cells hijack inflammatory mechanisms to promote their own growth. IL-6 is one of the major cytokines, and is frequently upregulated in tumors. The pentose phosphate pathway (PPP) generates the indispensable building blocks to produce various nucleotides. Here we aimed to determine w...

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Detalles Bibliográficos
Autores principales: Qiu, Xuemei, Ye, Hongping, Li, Xiaofei, Li, Dan, Jiang, Lu, Liu, Rui, Zhao, Zhe, He, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692918/
https://www.ncbi.nlm.nih.gov/pubmed/37949355
http://dx.doi.org/10.1016/j.molmet.2023.101836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692918/
https://www.ncbi.nlm.nih.gov/pubmed/37949355
http://dx.doi.org/10.1016/j.molmet.2023.101836

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