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IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growth
OBJECTIVE: Tumor cells hijack inflammatory mechanisms to promote their own growth. IL-6 is one of the major cytokines, and is frequently upregulated in tumors. The pentose phosphate pathway (PPP) generates the indispensable building blocks to produce various nucleotides. Here we aimed to determine w...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692918/ https://www.ncbi.nlm.nih.gov/pubmed/37949355 http://dx.doi.org/10.1016/j.molmet.2023.101836 |