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Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study
BACKGROUND AND OBJECTIVES: Breast cancer is currently the most commonly diagnosed neoplasm in women worldwide. There is evidence that human papillomavirus (HPV) infection may play a key role in breast cancer aggressiveness, but results are conflicting across studies. The aim of this study was to inv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Tehran University of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692969/ https://www.ncbi.nlm.nih.gov/pubmed/38045712 http://dx.doi.org/10.18502/ijm.v15i4.13513 |
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author | Makvandi, Manoochehr Rashno, Mohammad Faghihloo, Ebrahim Bagheri, Shahram Hesam, Saeed Mirzaei, Habibollah Ramezani, Ali |
author_facet | Makvandi, Manoochehr Rashno, Mohammad Faghihloo, Ebrahim Bagheri, Shahram Hesam, Saeed Mirzaei, Habibollah Ramezani, Ali |
author_sort | Makvandi, Manoochehr |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Breast cancer is currently the most commonly diagnosed neoplasm in women worldwide. There is evidence that human papillomavirus (HPV) infection may play a key role in breast cancer aggressiveness, but results are conflicting across studies. The aim of this study was to investigate the presence of the HPV viral genome in benign and malignant breast tissue samples and its clinicopathological characteristics of cancer. MATERIALS AND METHODS: In this case-control study, 100 formalin-fixed paraffin-embedded (FFPE) of breast cancer and 100 blocks of non-cancerous breast tissue were selected as a control group from the pathology department of Imam Khomeini Hospital in Ahvaz from 2020–2022. The presence of HPV was detected using nested PCR including MY09/11 primers and sequencing were performed for virus genotyping. RESULTS: The present study enrolled 100 subjects each in two cancer and control groups with a mean age of 52.81±13.23 and 35.77±11.65, respectively. The risk of cancer in HPV-infected patients is almost 5 times higher than in HPV-negative individuals, it is not statistically significant (OR =4.99, 95% CI 0.35 to 72.15, p=0.238). The prevalence of HPV in the cancer and control groups was 7% and 1%, respectively and HPVs detected in two groups were of the HPV 16 genotype. Although the chance of ER and PR expression, lymphvascular involvement, perineural invasion, and higher tumor grade was higher in HPV-positive subjects than in HPV-negative subjects, this was not statistically significant (OR>1, p>0.05). CONCLUSION: Based on studies reporting the existence of sequences of different high-risk HPV types (oncogenes) in breast cancer tissues, this study confirmed the hypothesis of a possible infectious cause in the development of breast cancer. So far, however, the results have been controversial and inconclusive. Further studies with large sample sizes are needed to demonstrate the link between HPV and breast cancer. |
format | Online Article Text |
id | pubmed-10692969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-106929692023-12-03 Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study Makvandi, Manoochehr Rashno, Mohammad Faghihloo, Ebrahim Bagheri, Shahram Hesam, Saeed Mirzaei, Habibollah Ramezani, Ali Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Breast cancer is currently the most commonly diagnosed neoplasm in women worldwide. There is evidence that human papillomavirus (HPV) infection may play a key role in breast cancer aggressiveness, but results are conflicting across studies. The aim of this study was to investigate the presence of the HPV viral genome in benign and malignant breast tissue samples and its clinicopathological characteristics of cancer. MATERIALS AND METHODS: In this case-control study, 100 formalin-fixed paraffin-embedded (FFPE) of breast cancer and 100 blocks of non-cancerous breast tissue were selected as a control group from the pathology department of Imam Khomeini Hospital in Ahvaz from 2020–2022. The presence of HPV was detected using nested PCR including MY09/11 primers and sequencing were performed for virus genotyping. RESULTS: The present study enrolled 100 subjects each in two cancer and control groups with a mean age of 52.81±13.23 and 35.77±11.65, respectively. The risk of cancer in HPV-infected patients is almost 5 times higher than in HPV-negative individuals, it is not statistically significant (OR =4.99, 95% CI 0.35 to 72.15, p=0.238). The prevalence of HPV in the cancer and control groups was 7% and 1%, respectively and HPVs detected in two groups were of the HPV 16 genotype. Although the chance of ER and PR expression, lymphvascular involvement, perineural invasion, and higher tumor grade was higher in HPV-positive subjects than in HPV-negative subjects, this was not statistically significant (OR>1, p>0.05). CONCLUSION: Based on studies reporting the existence of sequences of different high-risk HPV types (oncogenes) in breast cancer tissues, this study confirmed the hypothesis of a possible infectious cause in the development of breast cancer. So far, however, the results have been controversial and inconclusive. Further studies with large sample sizes are needed to demonstrate the link between HPV and breast cancer. Tehran University of Medical Sciences 2023-08 /pmc/articles/PMC10692969/ /pubmed/38045712 http://dx.doi.org/10.18502/ijm.v15i4.13513 Text en Copyright © 2023 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Makvandi, Manoochehr Rashno, Mohammad Faghihloo, Ebrahim Bagheri, Shahram Hesam, Saeed Mirzaei, Habibollah Ramezani, Ali Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title | Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title_full | Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title_fullStr | Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title_full_unstemmed | Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title_short | Low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
title_sort | low presence of papillomavirus and its lack of correlation with clinicopathological factors in breast cancer: a case control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692969/ https://www.ncbi.nlm.nih.gov/pubmed/38045712 http://dx.doi.org/10.18502/ijm.v15i4.13513 |
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