Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

BACKGROUND: Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative feature of NREM sleep and is important for memory consolidation. METHODS: We gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Qiuchen, Maci, Megi, Miller, Morgan R., Zhou, Heng, Zhang, Fang, Algamal, Moustafa, Lee, Yee Fun, Hou, Steven S., Perle, Stephen J., Le, Hoang, Russ, Alyssa N., Lo, Eng H., Gerashchenko, Dmitry, Gomperts, Stephen N., Bacskai, Brian J., Kastanenka, Ksenia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693059/
https://www.ncbi.nlm.nih.gov/pubmed/38041158
http://dx.doi.org/10.1186/s13024-023-00682-9

Ejemplares similares

Ejemplares similares