Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models

BACKGROUND: Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggable member...

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Detalles Bibliográficos
Autores principales: Lepore Signorile, Martina, Fasano, Candida, Forte, Giovanna, De Marco, Katia, Sanese, Paola, Disciglio, Vittoria, Di Nicola, Elisabetta, Pantaleo, Antonino, Simone, Cristiano, Grossi, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693086/
https://www.ncbi.nlm.nih.gov/pubmed/38041178
http://dx.doi.org/10.1186/s13578-023-01175-4

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