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The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges
Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693092/ https://www.ncbi.nlm.nih.gov/pubmed/38042824 http://dx.doi.org/10.1186/s13020-023-00861-2 |
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author | Ge, Feilin Yang, Yan Bai, Zhaofang Si, Lanlan Wang, Xuemei Yu, Jia Xiao, Xiaohe Liu, Yan Ren, Zhigang |
author_facet | Ge, Feilin Yang, Yan Bai, Zhaofang Si, Lanlan Wang, Xuemei Yu, Jia Xiao, Xiaohe Liu, Yan Ren, Zhigang |
author_sort | Ge, Feilin |
collection | PubMed |
description | Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen inhibition, drug resistance, low-level viremia, restricting patients' functional cure. Due to the constraints of NAs, traditional medicines, such as traditional Chinese medicine (TCM), have become more prevalently used and researched in the clinical treatment of CHB as complementary alternative therapies. As a consequence, the review focuses on the background based on HBV’s life cycle as well as the NAs’ limitations, progress based on direct and indirect pathway of targeting HBV of TCM, and challenges of TCM. We found TCMs play an increasingly important role in anti-HBV. In a direct antiviral way, they regulate HBV infection, replication, assembly, and other aspects of the HBV life cycle. As for indirect way, TCMs can exert anti-HBV effects through targeting the host, including immune regulation, apoptosis, autophagy, oxidative stress, etc. Especially, TCMs have the advantages of strong antigenic inhibition compared to NAs. Specifically, we can combine the benefits of TCMs in strong HBV antigen inhibition with the benefits of NAs in targeted antiviral effects, in order to find a suitable combination of "TCM + NAs" to contribute to Chinese knowledge of the realisation of the “global elimination of HBV by 2030” goal of the World Health Organization. |
format | Online Article Text |
id | pubmed-10693092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106930922023-12-03 The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges Ge, Feilin Yang, Yan Bai, Zhaofang Si, Lanlan Wang, Xuemei Yu, Jia Xiao, Xiaohe Liu, Yan Ren, Zhigang Chin Med Review Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen inhibition, drug resistance, low-level viremia, restricting patients' functional cure. Due to the constraints of NAs, traditional medicines, such as traditional Chinese medicine (TCM), have become more prevalently used and researched in the clinical treatment of CHB as complementary alternative therapies. As a consequence, the review focuses on the background based on HBV’s life cycle as well as the NAs’ limitations, progress based on direct and indirect pathway of targeting HBV of TCM, and challenges of TCM. We found TCMs play an increasingly important role in anti-HBV. In a direct antiviral way, they regulate HBV infection, replication, assembly, and other aspects of the HBV life cycle. As for indirect way, TCMs can exert anti-HBV effects through targeting the host, including immune regulation, apoptosis, autophagy, oxidative stress, etc. Especially, TCMs have the advantages of strong antigenic inhibition compared to NAs. Specifically, we can combine the benefits of TCMs in strong HBV antigen inhibition with the benefits of NAs in targeted antiviral effects, in order to find a suitable combination of "TCM + NAs" to contribute to Chinese knowledge of the realisation of the “global elimination of HBV by 2030” goal of the World Health Organization. BioMed Central 2023-12-02 /pmc/articles/PMC10693092/ /pubmed/38042824 http://dx.doi.org/10.1186/s13020-023-00861-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Ge, Feilin Yang, Yan Bai, Zhaofang Si, Lanlan Wang, Xuemei Yu, Jia Xiao, Xiaohe Liu, Yan Ren, Zhigang The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title_full | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title_fullStr | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title_full_unstemmed | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title_short | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
title_sort | role of traditional chinese medicine in anti-hbv: background, progress, and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693092/ https://www.ncbi.nlm.nih.gov/pubmed/38042824 http://dx.doi.org/10.1186/s13020-023-00861-2 |
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