Aging gene signature of memory CD8(+) T cells is associated with neurocognitive functioning in Alzheimer’s disease

BACKGROUND: Memory CD8(+) T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8(+) T cells expressing low levels of IL-7 receptor alpha (IL-7Rα(low)) and the presence of its gene signature (i.e., IL-7Rα(low) aging genes) in peripheral blood of ol...

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Detalles Bibliográficos
Autores principales: Young, Juan Joseph, Park, Hong-Jai, Kim, Minhyung, Par-Young, Jennefer, Bartlett, Hugh, Kim, Hye Sun, Unlu, Serhan, Osmani, Lais, Shin, Min Sun, Bucala, Richard, van Dyck, Christopher H., Allore, Heather, Mecca, Adam P., You, Sungyong, Kang, Insoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693128/
https://www.ncbi.nlm.nih.gov/pubmed/38042785
http://dx.doi.org/10.1186/s12979-023-00396-y

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