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Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect

PURPOSE: To develop an UPLC-MS/MS method for the quantitative analysis of pentoxifylline in beagle dog plasma and apply it to a pharmacokinetic study of food effect. METHODS: Sample separation was achieved using a Kinetex Phenyl-Hexyl column (50 × 2.1 mm, 1.7 μm) with a gradient elution program in 5...

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Detalles Bibliográficos
Autores principales:	Xu, Yuxiang, Gao, Xiaonan, Zhu, Yunfang, Zhang, Qi, Qie, Hongxin, Zhao, Haopeng, Gao, Jinglin, Wang, Mingxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693274/ https://www.ncbi.nlm.nih.gov/pubmed/38046282 http://dx.doi.org/10.2147/DDDT.S434492

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