Cargando…

Exosome Derived from Mesenchymal Stem Cells Alleviates Hypertrophic Scar by Inhibiting the Fibroblasts via TNFSF-13/HSPG2 Signaling Pathway

BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-exo) have been shown to have significant potential in wound healing and scar relief processes. According to reports, TNFSF13 and HSPG2 are associated with various fibrotic diseases. The aim of this study is to investigate how TNFSF13 and HSPG2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Huimin, Zang, Chengyu, Zhao, Wen, Zhang, Linfeng, Liu, Rui, Feng, Zhang, Wu, Jie, Cui, Rongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693282/ https://www.ncbi.nlm.nih.gov/pubmed/38046235 http://dx.doi.org/10.2147/IJN.S433510

Ejemplares similares

Exosome Derived from Mesenchymal Stem Cells Alleviates Pathological Scars by Inhibiting the Proliferation, Migration and Protein Expression of Fibroblasts via Delivering miR-138-5p to Target SIRT1
por: Zhao, Wen, et al.
Publicado: (2022)

Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation
por: Zhao, Wen, et al.
Publicado: (2023)

Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts
por: Li, Shiyi, et al.
Publicado: (2022)

Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin
por: Cui, Hui Song, et al.
Publicado: (2023)

Shikonin promotes hypertrophic scar repair by autophagy of hypertrophic scar-derived fibroblasts
por: Zhang, Qing, et al.
Publicado: (2023)

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts
por: Zeng, Jian, et al.
Publicado: (2020)

Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms
por: Zhong, Yixiu, et al.
Publicado: (2023)

Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring
por: Yates, Cecelia C., et al.
Publicado: (2017)

Associations between TNFSF4, TNFSF8 and TNFSF15 and Behçet's disease but not VKH syndrome in Han Chinese
por: Jiang, Yan, et al.
Publicado: (2017)

miR-495 inhibits the growth of fibroblasts in hypertrophic scars
por: Guo, Bingyu, et al.
Publicado: (2019)

Effect of THBS1 on the Biological Function of Hypertrophic Scar Fibroblasts
por: Jiang, D., et al.
Publicado: (2020)

The Effect of p38MAPK on Cyclic Stretch in Human Facial Hypertrophic Scar Fibroblast Differentiation
por: Du, Qi-cui, et al.
Publicado: (2013)

KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription
por: Wang, Jing, et al.
Publicado: (2022)

Mesenchymal stem cell therapy in hypertrophic and keloid scars
por: Bojanic, Christine, et al.
Publicado: (2021)

TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
por: da Silva Antunes, Ricardo, et al.
Publicado: (2018)

Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients
por: Fan, Huifeng, et al.
Publicado: (2021)

sncRNA changes induced by tension in hypertrophic scar: sncRNAs in hypertrophic scar
por: Yin, Chuang, et al.
Publicado: (2022)

Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis
por: Xiao, Yongqiang, et al.
Publicado: (2019)

Abstract 3: Identification of Fibroblast Subtypes during Hypertrophic Scar Development
por: Kuehlmann, Britta, et al.
Publicado: (2017)

MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1
por: Zhang, Yi, et al.
Publicado: (2018)

Adipose-derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic-scar and keloid fibroblasts
por: Xie, Fang, et al.
Publicado: (2021)

Is HSPG2 a modifier gene for Marfan syndrome?
por: Gerdes Gyuricza, Isabela, et al.
Publicado: (2020)

The HSPG syndecan is a core organizer of cholinergic synapses
por: Zhou, Xin, et al.
Publicado: (2021)

Interleukin-10-Modified Adipose-Derived Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Regulating the Biological Characteristics of Fibroblasts and Inflammation
por: Xie, Fang, et al.
Publicado: (2022)

Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts via Inhibiting the Phosphorylation of AKT
por: Wu, Xue, et al.
Publicado: (2020)

Medicinal Plants for the Treatment of Hypertrophic Scars
por: Ye, Qi, et al.
Publicado: (2015)

TNFSF13 Is a Novel Onco-Inflammatory Marker and Correlates With Immune Infiltration in Gliomas
por: Chen, Rui, et al.
Publicado: (2021)

Effect of pressure therapy for treatment of hypertrophic scar
por: Zhang, Hao, et al.
Publicado: (2019)

Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition
por: Deng, Xingwang, et al.
Publicado: (2021)

Simvastatin cream alleviates dermal fibrosis in a rabbit ear hypertrophic scar model
por: Dolivo, David, et al.
Publicado: (2022)

A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K/AKT and MAPK signaling pathways in hypertrophic scar: FPASL regulates hypertrophic scar via the AKT and MAPK pathways
por: Ma, Fang, et al.
Publicado: (2022)

Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts
por: Li, Jie, et al.
Publicado: (2021)

HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas
por: Wiweger, Malgorzata I., et al.
Publicado: (2012)

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions
por: Martinez, Jerahme R., et al.
Publicado: (2018)

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar Fibroblasts
por: Zhu, Hua-Yu, et al.
Publicado: (2014)

Smad-binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts
por: Fan, Chen, et al.
Publicado: (2020)

Silicone Gel for Hypertrophic Scars
por: Wiwanitkit, Viroj
Publicado: (2010)

Update on hypertrophic scar treatment
por: Rabello, Felipe Bettini, et al.
Publicado: (2014)

Burns, hypertrophic scar and galactorrhea
por: Karimi, Hamid, et al.
Publicado: (2013)

The molecular basis of hypertrophic scars
por: Zhu, Zhensen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dgpu28v013dqenafun2djoe78p