Cargando…

New Insights Into Pyridoxal Kinase Inhibitors and Their Antileukemic Effects

Pyridoxal kinase (PDXK) plays a pivotal role as an essential enzyme in cellular processes. It catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine to generate pyridoxal 5'-phosphate (PLP), the bioactive form of vitamin B6. An intriguing link has emerged between elevated expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Banerjee, Pallabi, Singh, Tripti, Qamar, Imteyaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cureus 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693352/ https://www.ncbi.nlm.nih.gov/pubmed/38046746 http://dx.doi.org/10.7759/cureus.48176

Ejemplares similares

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition
por: Gandhi, Amit K., et al.
Publicado: (2012)

Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase
por: Ghatge, Mohini S., et al.
Publicado: (2012)

Traditional Nutritional and Health Practices Targeting Lifestyle Behavioral Changes in Humans
por: Singh, Aditi, et al.
Publicado: (2020)

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia
por: Bridges, Cory Seth, et al.
Publicado: (2022)

Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen
por: Devi, Suneeta, et al.
Publicado: (2021)

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate
por: Filipowicz, A, et al.
Publicado: (2012)

A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology
por: Kagan, Amanda B., et al.
Publicado: (2022)

Optimization of Tyrosine Kinase Inhibitor-Loaded Gold Nanoparticles for Stimuli-Triggered Antileukemic Drug Release
por: Tatar, Andra-Sorina, et al.
Publicado: (2023)

Natural product P57 induces hypothermia through targeting pyridoxal kinase
por: Wang, Ruina, et al.
Publicado: (2023)

L-Ascorbic Acid and α-Tocopherol Synergistically Triggers Apoptosis Inducing Antileukemic Effects of Arsenic Trioxide via Oxidative Stress in Human Acute Promyelocytic Leukemia Cells
por: Vineetha, Radhakrishnan Chandraprabha, et al.
Publicado: (2020)

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia
por: Kaiser, M, et al.
Publicado: (2011)

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
por: Etchin, J, et al.
Publicado: (2013)

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
por: Meunier, Godelieve, et al.
Publicado: (2020)

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
por: Jones, Deuan C, et al.
Publicado: (2012)

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
por: Mascolo, Elisa, et al.
Publicado: (2019)

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
por: Joseph, Adrien, et al.
Publicado: (2021)

Copy Number Alterations in CDKN2A/2B and MTAP Genes Are Associated With Low MEF2C Expression in T-cell Acute Lymphoblastic Leukemia
por: Kumari, Sarita, et al.
Publicado: (2022)

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2
por: Tramonti, Angela, et al.
Publicado: (2021)

Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression
por: Chandra, Anshuman, et al.
Publicado: (2020)

Antileukemic activity of novel adenosine derivatives
por: Poczta, Anastazja, et al.
Publicado: (2019)

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes
por: Soo, Valerie W. C., et al.
Publicado: (2016)

PPARγ ligands increase antileukemic activity of second- and third-generation tyrosine kinase inhibitors in chronic myeloid leukemia cells
por: Glodkowska-Mrowka, E, et al.
Publicado: (2016)

HDAC Inhibitor LBH589 Suppresses the Proliferation but Enhances the Antileukemic Effect of Human γδT Cells
por: He, Ying, et al.
Publicado: (2020)

Cloning, purification and preliminary crystallographic analysis of a putative pyridoxal kinase from Bacillus subtilis
por: Newman, Joseph A., et al.
Publicado: (2006)

Insights into Asparaginase from Endophytic Fungus Lasiodiplodia theobromae: Purification, Characterization and Antileukemic Activity
por: Moubasher, Hani A., et al.
Publicado: (2022)

Association of Serum Pyridoxal-5′-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study
por: Xu, Lei, et al.
Publicado: (2022)

Selective targeting of the mTORC1/2 protein kinase complexes leads to antileukemic effects in vitro and in vivo
por: Schuster, K, et al.
Publicado: (2011)

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
por: Eriksson, A, et al.
Publicado: (2012)

Attenuating homologous recombination stimulates an AID-induced antileukemic effect
por: Lamont, Kristin R., et al.
Publicado: (2013)

The synergistic antileukemic effects of eltrombopag and decitabine in myeloid leukemia cells
por: Shi, Mingyue, et al.
Publicado: (2019)

Enzyme-independent catabolism of cysteine with pyridoxal-5′-phosphate
por: Mulay, Prajakatta, et al.
Publicado: (2023)

Improving Outcomes of Tyrosine Kinase Inhibitors in Hepatocellular Carcinoma: New Data and Ongoing Trials
por: Mou, Lisha, et al.
Publicado: (2021)

Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer
por: Howard, David, et al.
Publicado: (2022)

Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies
por: Kohl, Vanessa, et al.
Publicado: (2019)

Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
por: Nik Man, Nik Muhd Khuzaimi, et al.
Publicado: (2015)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
por: Rahman, Heshu Sulaiman, et al.
Publicado: (2013)

Comparison of in vitro antileukemic activity of obatoclax and ABT-737
por: Opydo-Chanek, Małgorzata, et al.
Publicado: (2016)

Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
por: Shida, Wataru, et al.
Publicado: (2019)

Classification of Congeneric and QSAR of Homologous Antileukemic S–Alkylcysteine Ketones
por: Castellano, Gloria, et al.
Publicado: (2021)

The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
por: Wang, Kuan-Chih, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3pga62638cj498s6d32kmcqbtg