Ga68-FAPI Imaging and Lu177-FAPI Therapy in a Case of Metastatic Solitary Fibrous Tumor

Solitary fibrous tumor (SFT) of the central nervous system (previously called hemangiopericytoma) is a rare mesenchymal tumor. Malignant SFT has a tendency to recur after surgery and can metastasize to distant organs. Treatment options for metastatic disease are limited. This case demonstrated high expression of FAP (fibroblast activating protein) in all metastatic sites with Ga-FAPI positron emission tomography–computed tomography imaging. Subsequently, the patient was treated with Lu177-FAPI-targeted radionuclide therapy. There was significant clinical response. There was mild partial morphological response seen on follow-up imaging.