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Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining

As one of the leading causes for dementia in the population, it is imperative that we discern exactly why Alzheimer’s disease (AD) has a strong molecular association with beta-amyloid and tau. Although a clear understanding about etiology and pathogenesis of AD remains unsolved, scientists worldwide...

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Autores principales: Zhang, Bide, Lage-Rupprecht, Vanessa, Wegner, Philipp, Sargsyan, Astghik, Gebel, Stephan, Jacobs, Marc, Klein, Jürgen, Hofmann-Apitius, Martin, Tom Kodamullil, Alpha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693436/
https://www.ncbi.nlm.nih.gov/pubmed/38041858
http://dx.doi.org/10.1093/database/baad085
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author Zhang, Bide
Lage-Rupprecht, Vanessa
Wegner, Philipp
Sargsyan, Astghik
Gebel, Stephan
Jacobs, Marc
Klein, Jürgen
Hofmann-Apitius, Martin
Tom Kodamullil, Alpha
author_facet Zhang, Bide
Lage-Rupprecht, Vanessa
Wegner, Philipp
Sargsyan, Astghik
Gebel, Stephan
Jacobs, Marc
Klein, Jürgen
Hofmann-Apitius, Martin
Tom Kodamullil, Alpha
author_sort Zhang, Bide
collection PubMed
description As one of the leading causes for dementia in the population, it is imperative that we discern exactly why Alzheimer’s disease (AD) has a strong molecular association with beta-amyloid and tau. Although a clear understanding about etiology and pathogenesis of AD remains unsolved, scientists worldwide have dedicated significant efforts to discovering the molecular interactions linked to the pathological characteristics and potential treatments. Knowledge representations, such as domain ontologies encompassing our current understanding about AD, could greatly assist and contribute to disease research. This paper describes the construction and application of the integrated Alzheimer’s Disease Ontology (ADO), combining selected concepts from the former version of the ADO and the Alzheimer’s Disease Mapping Ontology (ADMO). In addition to the existing entities available from these knowledge models, essential knowledge about AD from public sources, such as newly discovered risk factor genes and novel treatments, was also integrated. The ADO can also be leveraged in text mining scenarios given that it is conceptually enriched with domain-specific knowledge as well as their relations. The integrated ADO consists of 39 855 total axioms. The ontology covers many aspects of the AD domain, including risk factor genes, clinical features, treatments and experimental models. The ontology complies with the Open Biological and Biomedical Ontology principles and was accepted by the foundry. In this paper, we illustrate the role of the presented ontology in extracting textual information from the SCAIView database and key measures in an ADO-based corpus. Database URL:  https://academic.oup.com/database
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spelling pubmed-106934362023-12-03 Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining Zhang, Bide Lage-Rupprecht, Vanessa Wegner, Philipp Sargsyan, Astghik Gebel, Stephan Jacobs, Marc Klein, Jürgen Hofmann-Apitius, Martin Tom Kodamullil, Alpha Database (Oxford) Original Article As one of the leading causes for dementia in the population, it is imperative that we discern exactly why Alzheimer’s disease (AD) has a strong molecular association with beta-amyloid and tau. Although a clear understanding about etiology and pathogenesis of AD remains unsolved, scientists worldwide have dedicated significant efforts to discovering the molecular interactions linked to the pathological characteristics and potential treatments. Knowledge representations, such as domain ontologies encompassing our current understanding about AD, could greatly assist and contribute to disease research. This paper describes the construction and application of the integrated Alzheimer’s Disease Ontology (ADO), combining selected concepts from the former version of the ADO and the Alzheimer’s Disease Mapping Ontology (ADMO). In addition to the existing entities available from these knowledge models, essential knowledge about AD from public sources, such as newly discovered risk factor genes and novel treatments, was also integrated. The ADO can also be leveraged in text mining scenarios given that it is conceptually enriched with domain-specific knowledge as well as their relations. The integrated ADO consists of 39 855 total axioms. The ontology covers many aspects of the AD domain, including risk factor genes, clinical features, treatments and experimental models. The ontology complies with the Open Biological and Biomedical Ontology principles and was accepted by the foundry. In this paper, we illustrate the role of the presented ontology in extracting textual information from the SCAIView database and key measures in an ADO-based corpus. Database URL:  https://academic.oup.com/database Oxford University Press 2023-12-02 /pmc/articles/PMC10693436/ /pubmed/38041858 http://dx.doi.org/10.1093/database/baad085 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zhang, Bide
Lage-Rupprecht, Vanessa
Wegner, Philipp
Sargsyan, Astghik
Gebel, Stephan
Jacobs, Marc
Klein, Jürgen
Hofmann-Apitius, Martin
Tom Kodamullil, Alpha
Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title_full Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title_fullStr Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title_full_unstemmed Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title_short Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
title_sort design of the formalized and integrated alzheimer’s disease ontology and its application in retrieving textual data via text mining
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693436/
https://www.ncbi.nlm.nih.gov/pubmed/38041858
http://dx.doi.org/10.1093/database/baad085
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