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450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions

OBJECTIVE: To explore the feasibility, safety and effectiveness of the 450-nm blue diode laser (BL), novel blue laser in the treatment of upper tract urothelial carcinomas (UTUCs) and other lesions in a porcine model. MATERIAL AND METHODS: For in vitro experiment, the ureter tissue was vaporised and...

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Autores principales: Jiang, Dali, Liu, Guoxiong, Yang, Bing, Niu, Haoming, Fan, Hengtong, Ren, Zejun, Mu, Liyue, Xu, Xiaofeng, Qiao, Ximin, Wu, Kaijie, He, Dalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693503/
https://www.ncbi.nlm.nih.gov/pubmed/37833548
http://dx.doi.org/10.1007/s00345-023-04647-x
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author Jiang, Dali
Liu, Guoxiong
Yang, Bing
Niu, Haoming
Fan, Hengtong
Ren, Zejun
Mu, Liyue
Xu, Xiaofeng
Qiao, Ximin
Wu, Kaijie
He, Dalin
author_facet Jiang, Dali
Liu, Guoxiong
Yang, Bing
Niu, Haoming
Fan, Hengtong
Ren, Zejun
Mu, Liyue
Xu, Xiaofeng
Qiao, Ximin
Wu, Kaijie
He, Dalin
author_sort Jiang, Dali
collection PubMed
description OBJECTIVE: To explore the feasibility, safety and effectiveness of the 450-nm blue diode laser (BL), novel blue laser in the treatment of upper tract urothelial carcinomas (UTUCs) and other lesions in a porcine model. MATERIAL AND METHODS: For in vitro experiment, the ureter tissue was vaporised and coagulated with BL, green-light laser (GL) and Ho:YAG laser (Ho). The efficiency, width and depth of vaporisation, and depth of coagulation were recorded and compared. For in vivo experiments, four swines weighing 70 kg were used. In the acute group, different modes of operations were performed to evaluate the thermal damage, perforation and bleeding. In the chronic group, the overall appearance of the ureter and laser wound healing were observed by the naked eyes and H&E staining 3 weeks after surgery. RESULTS: In in vitro study, the BL showed a higher efficiency of tissue vaporisation and less tissue coagulation for fresh ureter compared to GL and Ho. In the in vivo study, the power of BL set at 7 W was better, and the thickness of thermal damage varied with different surgery types in the range of 74–306 μm. After 3 weeks, the wound healed well static in vaporisation (SV), moving vaporisation (MV) and H&E staining indicated mucosal healing rather than scar healing. CONCLUSION: 5–10W blue diode laser achieved a higher efficiency of tissue vaporisation and less tissue coagulation in a porcine model, indicating its potential application in the endoscopic surgery of UTUC as an optional device with high performance and safety.
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spelling pubmed-106935032023-12-04 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions Jiang, Dali Liu, Guoxiong Yang, Bing Niu, Haoming Fan, Hengtong Ren, Zejun Mu, Liyue Xu, Xiaofeng Qiao, Ximin Wu, Kaijie He, Dalin World J Urol Original Article OBJECTIVE: To explore the feasibility, safety and effectiveness of the 450-nm blue diode laser (BL), novel blue laser in the treatment of upper tract urothelial carcinomas (UTUCs) and other lesions in a porcine model. MATERIAL AND METHODS: For in vitro experiment, the ureter tissue was vaporised and coagulated with BL, green-light laser (GL) and Ho:YAG laser (Ho). The efficiency, width and depth of vaporisation, and depth of coagulation were recorded and compared. For in vivo experiments, four swines weighing 70 kg were used. In the acute group, different modes of operations were performed to evaluate the thermal damage, perforation and bleeding. In the chronic group, the overall appearance of the ureter and laser wound healing were observed by the naked eyes and H&E staining 3 weeks after surgery. RESULTS: In in vitro study, the BL showed a higher efficiency of tissue vaporisation and less tissue coagulation for fresh ureter compared to GL and Ho. In the in vivo study, the power of BL set at 7 W was better, and the thickness of thermal damage varied with different surgery types in the range of 74–306 μm. After 3 weeks, the wound healed well static in vaporisation (SV), moving vaporisation (MV) and H&E staining indicated mucosal healing rather than scar healing. CONCLUSION: 5–10W blue diode laser achieved a higher efficiency of tissue vaporisation and less tissue coagulation in a porcine model, indicating its potential application in the endoscopic surgery of UTUC as an optional device with high performance and safety. Springer Berlin Heidelberg 2023-10-13 2023 /pmc/articles/PMC10693503/ /pubmed/37833548 http://dx.doi.org/10.1007/s00345-023-04647-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Jiang, Dali
Liu, Guoxiong
Yang, Bing
Niu, Haoming
Fan, Hengtong
Ren, Zejun
Mu, Liyue
Xu, Xiaofeng
Qiao, Ximin
Wu, Kaijie
He, Dalin
450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title_full 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title_fullStr 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title_full_unstemmed 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title_short 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
title_sort 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693503/
https://www.ncbi.nlm.nih.gov/pubmed/37833548
http://dx.doi.org/10.1007/s00345-023-04647-x
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