Cargando…

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound’s toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carta, Giada, van der Stel, Wanda, Scuric, Emma W. J., Capinha, Liliana, Delp, Johannes, Bennekou, Susanne Hougaard, Forsby, Anna, Walker, Paul, Leist, Marcel, van de Water, Bob, Jennings, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693540/ https://www.ncbi.nlm.nih.gov/pubmed/37353587 http://dx.doi.org/10.1007/s10565-023-09816-7

Ejemplares similares

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
por: Delp, Johannes, et al.
Publicado: (2021)

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals
por: van der Stel, Wanda, et al.
Publicado: (2020)

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
por: van der Stel, Wanda, et al.
Publicado: (2021)

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models
por: Capinha, Liliana, et al.
Publicado: (2022)

Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience
por: Moné, M. J., et al.
Publicado: (2020)

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
por: Terron, Andrea, et al.
Publicado: (2017)

Moving towards a holistic approach for human health risk assessment – Is the current approach fit for purpose?
por: Bennekou, Susanne Hougaard
Publicado: (2019)

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
por: Loser, Dominik, et al.
Publicado: (2021)

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors
por: Yang, Huan, et al.
Publicado: (2021)

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk
por: Daneshian, Mardas, et al.
Publicado: (2016)

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq
por: Limonciel, Alice, et al.
Publicado: (2018)

High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors
por: van der Stel, Wanda, et al.
Publicado: (2022)

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
por: Loser, Dominik, et al.
Publicado: (2021)

Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia
por: Liu, Qiuyu, et al.
Publicado: (2023)

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds
por: Duijndam, Britt, et al.
Publicado: (2021)

Targeting the Heterogeneous Genomic Landscape in Triple-Negative Breast Cancer through Inhibitors of the Transcriptional Machinery
por: van der Noord, Vera E., et al.
Publicado: (2022)

“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism
por: van Vugt-Lussenburg, Barbara M. A., et al.
Publicado: (2022)

Advancing human health risk assessment
por: Lanzoni, Anna, et al.
Publicado: (2019)

Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms
por: Bittenbinder, Matyas A., et al.
Publicado: (2023)

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors
por: van der Noord, Vera E., et al.
Publicado: (2023)

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
por: Zgheib, Elias, et al.
Publicado: (2019)

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
por: Zgheib, Elias, et al.
Publicado: (2018)

Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect
por: Secker, Philipp F., et al.
Publicado: (2018)

Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis
por: Schwaderer, Juliane, et al.
Publicado: (2020)

Establishment of cumulative assessment groups of pesticides for their effects on the thyroid
por: Crivellente, Federica, et al.
Publicado: (2019)

Establishment of cumulative assessment groups of pesticides for their effects on the nervous system
por: Crivellente, Federica, et al.
Publicado: (2019)

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia
por: Ockleford, Colin, et al.
Publicado: (2017)

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli
por: Gerding, Hanne R., et al.
Publicado: (2019)

Metapopulation capacity determines food chain length in fragmented landscapes
por: Wang, Shaopeng, et al.
Publicado: (2021)

Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
por: Wijaya, Lukas S., et al.
Publicado: (2021)

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress
por: Gutbier, Simon, et al.
Publicado: (2018)

Comparing in vitro human liver models to in vivo human liver using RNA-Seq
por: Gupta, Rajinder, et al.
Publicado: (2020)

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
por: Koedoot, Esmee, et al.
Publicado: (2019)

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
por: Drakvik, Elina, et al.
Publicado: (2019)

SARCOMAS IN HAMSTERS AFTER INJECTION WITH ROUS CHICKEN TUMOR MATERIAL
por: Ahlström, C. G., et al.
Publicado: (1962)

Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells
por: Jennings, Paul, et al.
Publicado: (2022)

Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
por: Craig, Peter S, et al.
Publicado: (2020)

Cumulative dietary risk characterisation of pesticides that have chronic effects on the thyroid
por: Craig, Peter S, et al.
Publicado: (2020)

Guidance on dermal absorption
por: Buist, Harrie, et al.
Publicado: (2017)

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
por: Gutbier, Simon, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jiiokkarm3qd6o0q72jnvaml0i