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Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential

While residual insecticide applications have the potential to decrease pathogen transmission by reducing the density of vectors and shifting the age structure of the adult mosquito population towards younger stages of development, this double entomological impact has not been documented for Aedes ae...

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Autores principales: Kirstein, Oscar David, Culquichicon, Carlos, Che-Mendoza, Azael, Navarrete-Carballo, Juan, Wang, Joyce, Bibiano-Marin, Wilberth, Gonzalez-Olvera, Gabriela, Ayora-Talavera, Guadalupe, Earnest, James, Puerta-Guardo, Henry, Pavia-Ruz, Norma, Correa-Morales, Fabian, Medina-Barreiro, Anuar, Manrique-Saide, Pablo, Vazquez-Prokopec, Gonzalo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693548/
https://www.ncbi.nlm.nih.gov/pubmed/38042955
http://dx.doi.org/10.1038/s41598-023-48620-5
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author Kirstein, Oscar David
Culquichicon, Carlos
Che-Mendoza, Azael
Navarrete-Carballo, Juan
Wang, Joyce
Bibiano-Marin, Wilberth
Gonzalez-Olvera, Gabriela
Ayora-Talavera, Guadalupe
Earnest, James
Puerta-Guardo, Henry
Pavia-Ruz, Norma
Correa-Morales, Fabian
Medina-Barreiro, Anuar
Manrique-Saide, Pablo
Vazquez-Prokopec, Gonzalo M.
author_facet Kirstein, Oscar David
Culquichicon, Carlos
Che-Mendoza, Azael
Navarrete-Carballo, Juan
Wang, Joyce
Bibiano-Marin, Wilberth
Gonzalez-Olvera, Gabriela
Ayora-Talavera, Guadalupe
Earnest, James
Puerta-Guardo, Henry
Pavia-Ruz, Norma
Correa-Morales, Fabian
Medina-Barreiro, Anuar
Manrique-Saide, Pablo
Vazquez-Prokopec, Gonzalo M.
author_sort Kirstein, Oscar David
collection PubMed
description While residual insecticide applications have the potential to decrease pathogen transmission by reducing the density of vectors and shifting the age structure of the adult mosquito population towards younger stages of development, this double entomological impact has not been documented for Aedes aegypti. Aedes collected from households enrolled in a cluster-randomized trial evaluating the epidemiological impact of targeted indoor residual spraying (TIRS) in Merida, Mexico, were dissected and their age structure characterized by the Polovodova combined with Christopher’s ovariole growth methods. In total, 813 females were dissected to characterize age structure at 1, 3, 6, and 9 months post-TIRS. Significant differences in the proportion of nulliparous Ae. aegypti females between the treatment groups was found at one-month post-TIRS (control: 35% vs. intervention: 59%), three months (20% vs. 49%) but not at six or nine months post-TIRS. TIRS significantly shiftted Ae. aegypti age structure towards younger stages and led to a non-linear reduction in survivorship compared to the control arm. Reduced survivorship also reduced the number of arbovirus transmitting females (those who survived the extrinsic incubation period). Our findings provide strong evidence of the full entomological impact of TIRS, with important implications for quantifying the epidemiological impact of vector control methods.
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spelling pubmed-106935482023-12-04 Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential Kirstein, Oscar David Culquichicon, Carlos Che-Mendoza, Azael Navarrete-Carballo, Juan Wang, Joyce Bibiano-Marin, Wilberth Gonzalez-Olvera, Gabriela Ayora-Talavera, Guadalupe Earnest, James Puerta-Guardo, Henry Pavia-Ruz, Norma Correa-Morales, Fabian Medina-Barreiro, Anuar Manrique-Saide, Pablo Vazquez-Prokopec, Gonzalo M. Sci Rep Article While residual insecticide applications have the potential to decrease pathogen transmission by reducing the density of vectors and shifting the age structure of the adult mosquito population towards younger stages of development, this double entomological impact has not been documented for Aedes aegypti. Aedes collected from households enrolled in a cluster-randomized trial evaluating the epidemiological impact of targeted indoor residual spraying (TIRS) in Merida, Mexico, were dissected and their age structure characterized by the Polovodova combined with Christopher’s ovariole growth methods. In total, 813 females were dissected to characterize age structure at 1, 3, 6, and 9 months post-TIRS. Significant differences in the proportion of nulliparous Ae. aegypti females between the treatment groups was found at one-month post-TIRS (control: 35% vs. intervention: 59%), three months (20% vs. 49%) but not at six or nine months post-TIRS. TIRS significantly shiftted Ae. aegypti age structure towards younger stages and led to a non-linear reduction in survivorship compared to the control arm. Reduced survivorship also reduced the number of arbovirus transmitting females (those who survived the extrinsic incubation period). Our findings provide strong evidence of the full entomological impact of TIRS, with important implications for quantifying the epidemiological impact of vector control methods. Nature Publishing Group UK 2023-12-02 /pmc/articles/PMC10693548/ /pubmed/38042955 http://dx.doi.org/10.1038/s41598-023-48620-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kirstein, Oscar David
Culquichicon, Carlos
Che-Mendoza, Azael
Navarrete-Carballo, Juan
Wang, Joyce
Bibiano-Marin, Wilberth
Gonzalez-Olvera, Gabriela
Ayora-Talavera, Guadalupe
Earnest, James
Puerta-Guardo, Henry
Pavia-Ruz, Norma
Correa-Morales, Fabian
Medina-Barreiro, Anuar
Manrique-Saide, Pablo
Vazquez-Prokopec, Gonzalo M.
Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title_full Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title_fullStr Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title_full_unstemmed Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title_short Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential
title_sort targeted indoor residual insecticide applications shift aedes aegypti age structure and arbovirus transmission potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693548/
https://www.ncbi.nlm.nih.gov/pubmed/38042955
http://dx.doi.org/10.1038/s41598-023-48620-5
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