Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

The attachment of the ubiquitin-like protein ISG15 to substrates by specific E1-E2-E3 enzymes is a well-established signalling mechanism of the innate immune response. Here, we present a 3.45 Å cryo-EM structure of a chemically trapped UBE1L-UBE2L6 complex bound to activated ISG15. This structure re...

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Detalles Bibliográficos
Autores principales: Wallace, Iona, Baek, Kheewoong, Prabu, J. Rajan, Vollrath, Ronnald, von Gronau, Susanne, Schulman, Brenda A., Swatek, Kirby N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693564/
https://www.ncbi.nlm.nih.gov/pubmed/38042859
http://dx.doi.org/10.1038/s41467-023-43711-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693564/
https://www.ncbi.nlm.nih.gov/pubmed/38042859
http://dx.doi.org/10.1038/s41467-023-43711-3

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