Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry

Off-target interactions between antisense oligonucleotides (ASOs) with state-of-the-art modifications and biological components still pose clinical safety liabilities. To mitigate a broad spectrum of off-target interactions and enhance the safety profile of ASO drugs, we here devise a nanoarchitectu...

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Detalles Bibliográficos
Autores principales: Terada, Chisato, Oh, Kaho, Tsubaki, Ryutaro, Chan, Bun, Aibara, Nozomi, Ohyama, Kaname, Shibata, Masa-Aki, Wada, Takehiko, Harada-Shiba, Mariko, Yamayoshi, Asako, Yamamoto, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693639/
https://www.ncbi.nlm.nih.gov/pubmed/38042877
http://dx.doi.org/10.1038/s41467-023-43714-0

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