Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for...

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Autores principales: Verweij, Paul E., Arendrup, Maiken C., Alastruey-Izquierdo, Ana, Gold, Jeremy A.W., Lockhart, Shawn R., Chiller, Tom, White, P.Lewis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693676/
https://www.ncbi.nlm.nih.gov/pubmed/36283187
http://dx.doi.org/10.1016/j.drup.2022.100885
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author Verweij, Paul E.
Arendrup, Maiken C.
Alastruey-Izquierdo, Ana
Gold, Jeremy A.W.
Lockhart, Shawn R.
Chiller, Tom
White, P.Lewis
author_facet Verweij, Paul E.
Arendrup, Maiken C.
Alastruey-Izquierdo, Ana
Gold, Jeremy A.W.
Lockhart, Shawn R.
Chiller, Tom
White, P.Lewis
author_sort Verweij, Paul E.
collection PubMed
description Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.
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spelling pubmed-106936762023-12-03 Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens? Verweij, Paul E. Arendrup, Maiken C. Alastruey-Izquierdo, Ana Gold, Jeremy A.W. Lockhart, Shawn R. Chiller, Tom White, P.Lewis Drug Resist Updat Article Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals. 2022-12 2022-10-20 /pmc/articles/PMC10693676/ /pubmed/36283187 http://dx.doi.org/10.1016/j.drup.2022.100885 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Verweij, Paul E.
Arendrup, Maiken C.
Alastruey-Izquierdo, Ana
Gold, Jeremy A.W.
Lockhart, Shawn R.
Chiller, Tom
White, P.Lewis
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title_full Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title_fullStr Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title_full_unstemmed Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title_short Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
title_sort dual use of antifungals in medicine and agriculture: how do we help prevent resistance developing in human pathogens?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693676/
https://www.ncbi.nlm.nih.gov/pubmed/36283187
http://dx.doi.org/10.1016/j.drup.2022.100885
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