Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice

Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic biomarker of Alzheimer’s disease. High levels of YKL-40 are associated with either advanced Al...

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Detalles Bibliográficos
Autores principales: Zeng, Xiaoyan, Cheung, Stanley K. K., Shi, Mengqi, Or, Penelope M. Y., Li, Zhining, Liu, Julia Y. H., Ho, Wayne L. H., Liu, Tian, Lu, Kun, Rudd, John A., Wang, Yubing, Chan, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693711/
https://www.ncbi.nlm.nih.gov/pubmed/38042775
http://dx.doi.org/10.1186/s12974-023-02970-z

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