Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives

Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psyc...

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Autores principales: Liu, Huanxi, Wang, Ligang, Yu, Hui, Chen, Jun, Sun, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693760/
https://www.ncbi.nlm.nih.gov/pubmed/38050614
http://dx.doi.org/10.2147/NDT.S433023
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author Liu, Huanxi
Wang, Ligang
Yu, Hui
Chen, Jun
Sun, Ping
author_facet Liu, Huanxi
Wang, Ligang
Yu, Hui
Chen, Jun
Sun, Ping
author_sort Liu, Huanxi
collection PubMed
description Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD.
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spelling pubmed-106937602023-12-04 Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives Liu, Huanxi Wang, Ligang Yu, Hui Chen, Jun Sun, Ping Neuropsychiatr Dis Treat Review Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD. Dove 2023-11-29 /pmc/articles/PMC10693760/ /pubmed/38050614 http://dx.doi.org/10.2147/NDT.S433023 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liu, Huanxi
Wang, Ligang
Yu, Hui
Chen, Jun
Sun, Ping
Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title_full Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title_fullStr Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title_full_unstemmed Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title_short Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
title_sort polygenic risk scores for bipolar disorder: progress and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693760/
https://www.ncbi.nlm.nih.gov/pubmed/38050614
http://dx.doi.org/10.2147/NDT.S433023
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