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Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine

PURPOSE: Thiopurine S-methyltransferase (TPMT) is an enzyme that metabolizes purine analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug metabolism leads to toxicity in chemotherapy patients and reduces treatment effectiveness. TPMT variants associated with reduced en...

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Detalles Bibliográficos
Autores principales:	Gallardo-Cóndor, Jennifer, Naranjo, Pablo, Atarihuana, Sebastián, Coello, Dayana, Guevara-Ramírez, Patricia, Flores-Espinoza, Rodrigo, Burgos, Germán, López-Cortés, Andrés, Cabrera-Andrade, Alejandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693761/ https://www.ncbi.nlm.nih.gov/pubmed/38050617 http://dx.doi.org/10.2147/TCRM.S432856

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